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2.A.108.2.11
Putative heavy metal transporter, Ftr1/Tp34 or Tpd, (TP0972/TP0971).  Ftr1 has 448 aas with 9 TMSs while Tp34 has 204 aas with 1 N-terminal TMSs. This antigen is a pathogen-specific membrane immunogen. This periplasmic dimeric protein binds human lactoferrin with submicromolar affinity with a stoichiometry of 2:1 (Deka et al. 2007).  It's 3-d structure (1.9 Å resolution) reveals two metal binding sites per monomer with zinc bound to both sites (Deka et al. 2007).

Accession Number:O83937
Protein Name:Conserved hypothetical integral membrane protein
Length:448
Molecular Weight:48456.00
Species:Treponema pallidum (strain Nichols) [243276]
Number of TMSs:9
Substrate Metal ions

Cross database links:

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  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERSWEGIDR GVPVYGMGCT MVAPGMPAAF ARSVVRASAW VGVALMCVAW SVSAAEGTRS 
61:	GGQAQERLSS WRQVVQRMEV HLRAAYTFFE SGDSDRAYEQ IDKAYFRYYE AKGMEKITMG 
121:	YLSGARKAAV ENAFFAYRRS VRGARDLAGV AFCRDKLVTM LYEDARALDG VARGRAGFAA 
181:	HIATFVASCV LVLREGIEAI LVIAAIVAYL VKTGKERCCA AVYAGAGAGV LFSVVLAVMI 
241:	VRVLGSEGGA AQEIIEGVGM FFAAAMLFYV SNWMLSKARA CAWDRYIRQK VERSVSRGNQ 
301:	WALVATAFLA VAREGAELIL FFRGIPVAGP YGRLAVWAAV TVSALVLVGV FVAIRFLSVR 
361:	LPLRPFFVAT GAVMYLLCFS FVGKGVSELQ EAGVVSRSTA PWMHGWSFDF LGIYPTYEGL 
421:	APQAFVVALV VLSAVWWCGG LCRGASST