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2.A.11.1.2
[Citrate]•M2+ (Ca2+ preferring):H+ symporter, CitH (transports Ca2+, Ba2+ & Sr2+).

Accession Number:P42308
Protein Name:CITN aka CitH aka N15CR
Length:426
Molecular Weight:45300.00
Species:Bacillus subtilis [1423]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+, Ba2+, Sr2+, H+

Cross database links:

HEGENOM: HBG297065
RefSeq: NP_391785.2   
Entrez Gene ID: 937469   
Pfam: PF03600   
KEGG: bsu:BSU39060   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015137 F:citrate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006101 P:citrate metabolic process
GO:0015746 P:citrate transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Sequencing of a 65 kb region of the Bacillus subtilis genome containing the lic and cel loci, and creation of a 177 kb contig covering the gnt-sacXY region.”  Yoshida K.et.al.   8969509
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706
[4] “Genes encoding xylan and beta-glucan hydrolysing enzymes in Bacillus subtilis: characterization, mapping and construction of strains deficient in lichenase, cellulase and xylanase.”  Wolf M.et.al.   7704256
[5] “Secondary transporters for citrate and the Mg(2+)-citrate complex in Bacillus subtilis are homologous proteins.”  Boorsma A.et.al.   8892821

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLAILGFVMM IVFMYLIMSN RLSALIALIV VPIVFALISG FGKDLGEMMI QGVTDLAPTG 
61:	IMLLFAILYF GIMIDSGLFD PLIAKILSFV KGDPLKIAVG TAVLTMTISL DGDGTTTYMI 
121:	TIAAMLPLYK RLGMNRLVLA GIAMLGSGVM NIIPWGGPTA RVLASLKLDT SEVFTPLIPA 
181:	MIAGILWVIA VAYILGKKER KRLGVISIDH APSSDPEAAP LKRPALQWFN LLLTVALMAA 
241:	LITSLLPLPV LFMTAFAVAL MVNYPNVKEQ QKRISAHAGN ALNVVSMVFA AGIFTGILSG 
301:	TKMVDAMAHS LVSLIPDAMG PHLPLITAIV SMPFTFFMSN DAFYFGVLPI IAEAASAYGI 
361:	DAAEIGRASL LGQPVHLLSP LVPSTYLLVG MAGVSFGDHQ KFTIKWAVGT TIVMTIAALL 
421:	IGIISF