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2.A.110.1.1
The endosomal/lysosomal heme transporter, HRG-1 (SLC48.1) (Yuan et al., 2012)

Accession Number:Q6P1K1
Protein Name:Heme transporter HRG1
Length:146
Molecular Weight:16419.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

HOG000069906HOG000069906
Genevestigator: Q6P1K1 Q6P1K1 Q6P1K1
eggNOG: prNOG21386 NOG39274 NOG39274
Entrez Gene ID: 55652   
KEGG: hsa:55652    hsa:55652    hsa:55652   

Gene Ontology

GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0006810 P:transport

References (9)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.”  Rajagopal A.et.al.   18418376
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.”  Rajagopal A.et.al.   18418376
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.”  Rajagopal A.et.al.   18418376

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPSRLQLGL RAAYSGISSV AGFSIFLVWT VVYRQPGTAA MGGLAGVLAL WVLVTHVMYM 
61:	QDYWRTWLKG LRGFFFVGVL FSAVSIAAFC TFLVLAITRH QSLTDPTSYY LSSVWSFISF 
121:	KWAFLLSLYA HRYRADFADI SILSDF