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2.A.110.1.2
The worm heme transporter, HRG-1 (Yuan et al., 2012).

Accession Number:Q21642
Protein Name:Heme transporter hrg-1
Length:194
Molecular Weight:21737.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

HEGENOM: HBG387906 HBG387906
Entrez Gene ID: 180684   
KEGG: cel:R02E12.6    cel:R02E12.6   

Gene Ontology

GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0020037 F:heme binding
GO:0015232 F:heme transporter activity

References (4)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.”  Rajagopal A.et.al.   18418376
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[4] “Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.”  Rajagopal A.et.al.   18418376

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MHQIYSSDVS SITSKSSIAK AEIITMEEEQ QRQSCCTWFH SLKVQIWIAW LGVSAGVMAG 
61:	TVFAIQYQNW IAVTMCFISS GFATLVLHLH LAYKKTQMAG WSETRLRCLA AVGATVSFLS 
121:	FIAMVFCLVV AGIEHQTLDK QGLMGANLWI AAVWFFMTSK WSALTWRFAR KYRAFCEESQ 
181:	PLLAAAPPEY SVTI