TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.110.1.1









The endosomal/lysosomal heme transporter, HRG-1 (SLC48.1) (Yuan et al., 2012)

Eukaryota
Metazoa
SLC48A1 of Homo sapiens
*2.A.110.1.2









The worm heme transporter, HRG-1 (Yuan et al., 2012).

Eukaryota
Metazoa
HRG1 of Caenorhabditis elegans (Q21642)
*2.A.110.1.3









HRG-4 heme transporter (Rajagopal et al. 2008).

Eukaryota
Metazoa
HRG-4 of Caenorhabditis elegans (Q20106)
*2.A.110.1.4









Putative heme transporter (151aas; 4 TMSs)

Eukaryota
Metazoa
Heme transporter of Branchiostoma floridae (C3Y137)
*2.A.110.1.5









Heme transporter Hrg-6 (Heme-responsive gene 6 protein) (CeHRG-6)

Eukaryota
Metazoa
Hrg-6 of Caenorhabditis elegans
*2.A.110.1.6









HRG homologue

Eukaryota
Longamoebia
HRG homologue of Acanthamoeba castellanii
*2.A.110.2.1









The LHR1 heme uptake transporter (Huynh et al. 2012).  In Leishmania amazonensis, LHR1 is essential for virulence (Miguel et al. 2013).  Transport depends on tyrosyl residues in the first three TMSs of the protein (Renberg et al. 2015).

Eukaryota
Kinetoplastida
LHR1 of Leishmania donovani (E9BH93)
*2.A.110.2.2









Heme uptake transporter, LHR1 (171aas; 4 putative TMSs) (Huynh et al. 2012).  Tyrosyl residues essential for activity are also essential for virulence (Renberg et al. 2015).

Eukaryota
Kinetoplastida
LHR1 of Trypanosoma cruzi (Q4DHZ7)