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2.A.110.2.1
The LHR1 heme uptake transporter (Huynh et al. 2012).  In Leishmania amazonensis, LHR1 is essential for virulence (Miguel et al. 2013).  Transport depends on tyrosyl residues in the first three TMSs of the protein (Renberg et al. 2015).

Accession Number:E9BH93
Protein Name:Hypothetical predicted multi-pass transmembrane protein
Length:175
Molecular Weight:19984.00
Species:Leishmania donovani (strain BPK282A1) [981087]
Number of TMSs:4
Substrate Heme

Cross database links:

HEGENOM: HOG000257681 HOG000257681

Gene Ontology

GO:0016021 C:integral to membrane

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNELERKRRT FRIWLAIYII FALAYLSGVL LFCFVHQNYW ACGGFVVVIL LIALRVALLA 
61:	TPQYRLYKIF PPCSFSRIAY QTFFLCACLV GISLGVWLMA RGIKHRQSWT ARSYFCGMTG 
121:	MWMAAKWSYI VTVPIYDLRE DTLEEDALIR LGLIDSGKDK ASGSNEPVTL KANCA