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2.A.112.1.1
The human KX blood group antigen (putative amino acid transporter), KX antigen (Suzuki et al. 2013).

Accession Number:P51811
Protein Name:MEMBRANE TRANSPORT PROTEIN XK (KX ANTIGEN) - Homo sapiens (Human).
Length:444
Molecular Weight:50902.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: P51811
eggNOG: prNOG17742
HEGENOM: HBG283821
RefSeq: NP_066569.1   
Entrez Gene ID: 7504   
Pfam: PF09815   
OMIM: 314850  gene+phenotype
KEGG: hsa:7504   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (8)

[1] “Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.”  Ho M.et.al.   8004674
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients.”  Khamlichi S.et.al.   7737196
[4] “Association of XK and Kell blood group proteins.”  Russo D.et.al.   9593744
[5] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[6] “McLeod neuroacanthocytosis: genotype and phenotype.”  Danek A.et.al.   11761473
[7] “Point mutations causing the McLeod phenotype.”  Russo D.C.et.al.   11961232
[8] “McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement.”  Jung H.H.et.al.   12823753

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFPASVLAS VFLFVAETTA ALSLSSTYRS GGDRMWQALT LLFSLLPCAL VQLTLLFVHR 
61:	DLSRDRPLVL LLHLLQLGPL FRCFEVFCIY FQSGNNEEPY VSITKKRQMP KNGLSEEIEK 
121:	EVGQAEGKLI THRSAFSRAS VIQAFLGSAP QLTLQLYISV MQQDVTVGRS LLMTISLLSI 
181:	VYGALRCNIL AIKIKYDEYE VKVKPLAYVC IFLWRSFEIA TRVVVLVLFT SVLKTWVVVI 
241:	ILINFFSFFL YPWILFWCSG SPFPENIEKA LSRVGTTIVL CFLTLLYTGI NMFCWSAVQL 
301:	KIDSPDLISK SHNWYQLLVY YMIRFIENAI LLLLWYLFKT DIYMYVCAPL LVLQLLIGYC 
361:	TAILFMLVFY QFFHPCKKLF SSSVSEGFQR WLRCFCWACR QQKPCEPIGK EDLQSSRDRD 
421:	ETPSSSKTSP EPGQFLNAED LCSA