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2.A.112.1.11
Xkr4 of 650 aas.  Catalyzes phosphatidyl serine flipping from the inner leaflet to the outer leaflet of the cell membrane to signal appoptosis.  It has a C-terminal caspase recognition signal that may play an important role.  Xkr4, 8 and 9 have this activity and have several essential residues in TMS2 and cytoplasmic loop 2 (Suzuki et al. 2014).

Accession Number:Q5GH76
Protein Name:XK-related protein 4
Length:650
Molecular Weight:71501.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate phospholipids

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAKSDGRLK MKKSSDVAFT PLQNSDHSGS VQGLAPGLPS GSGAEDEEAA GGGCCPDGGG 
61:	CSRCCCCCAG SGGSAGSGGS GGVAGPGGGG AGSAALCLRL GREQRRYSLW DCLWILAAVA 
121:	VYFADVGTDV WLAVDYYLRG QRWWFGLTLF FVVLGSLSVQ VFSFRWFVHD FSTEDSATAA 
181:	AASSCPQPGA DCKTVVGGGS AAGEGEARPS TPQRQASNAS KSNIAAANSG SNSSGATRAS 
241:	GKHRSASCSF CIWLLQSLIH ILQLGQIWRY FHTIYLGIRS RQSGENDRWR FYWKMVYEYA 
301:	DVSMLHLLAT FLESAPQLVL QLCIIVQTHS LQALQGFTAA ASLVSLAWAL ASYQKALRDS 
361:	RDDKKPISYM AVIIQFCWHF FTIAARVITF ALFASVFQLY FGIFIVLHWC IMTFWIVHCE 
421:	TEFCITKWEE IVFDMVVGII YIFSWFNVKE GRTRCRLFIY YFVILLENTA LSALWYLYKA 
481:	PQIADAFAIP ALCVVFSSFL TGVVFMLMYY AFFHPNGPRF GQSPSCACED PAAAFTLPPD 
541:	VATSTLRSIS NNRSVVSDRD QKFAERDGCV PVFQVRPTAP STPSSRPPRI EESVIKIDLF 
601:	RNRYPAWERH VLDRSLRKAI LAFECSPSPP RLQYKDDALI QERLEYETTL