TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.112.1.2
Cell death abnormality protein 8; phospholipid flippase (in to out) (Suzuki et al. 2013; Chen et al. 2013).

Accession Number:O17386
Protein Name:Cell death abnormality protein 8
Length:458
Molecular Weight:53273.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate phospholipids

Cross database links:

eggNOG: NOG283702 NOG283702
HEGENOM: HOG000022315 HOG000022315
Entrez Gene ID: 184190    184190   
Pfam: PF09815    PF09815   
KEGG: cel:F08F1.5    cel:F08F1.5   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006915 P:apoptotic process
GO:0006308 P:DNA catabolic process
GO:0009790 P:embryo development
GO:0012501 P:programmed cell death
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006915 P:apoptotic process
GO:0006308 P:DNA catabolic process
GO:0009790 P:embryo development
GO:0012501 P:programmed cell death

References (8)

[1] “The ced-8 gene controls the timing of programmed cell deaths in C. elegans.”  Stanfield G.M.et.al.   10882128
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.”  Ellis R.E.et.al.   1936965
[4] “Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.”  Gumienny T.L.et.al.   9927601
[5] “The ced-8 gene controls the timing of programmed cell deaths in C. elegans.”  Stanfield G.M.et.al.   10882128
[6] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[7] “Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.”  Ellis R.E.et.al.   1936965
[8] “Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.”  Gumienny T.L.et.al.   9927601

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MFLKKHKSKL LLVPRDEEQE DAGIVAVLTD RIPSVLLVRW FDLFCFGFAM CSYALDFFSD 
61:	IGIAIFHFWA GRYLSGSLVL AFALLPSVII NIISMVWMLD DEMHWKRRAH PRRTGTFELN 
121:	QKRFIPLSKM IVLCICQMGP LFWYYKALYY GWMFRKSSNE NTDGEKRKCF SKMVEAERDA 
181:	TLLRFFEAFL ESAPQLIIQG SIAASYFQNY YQTGTYPYWL YFQAASLLLS IISISWSVVV 
241:	QNRSLRMIRD DKVNIWPHEA VLQFCWRFLT ILARIITLVA LVLIFGINVV PLISVHLLVT 
301:	LVHVIFLQAI HIDACTHIEK LLLLINTFIH IFIPFNMVEG NTRWRYLTAY SVEFIEMMLV 
361:	CWLLPLSLNT FPYIEKVQVG VPISFIAGIA IMMMYYQFFH PNRRQLIVTQ SQEDLSLNVQ 
421:	KSVETLTPKL ESSLEISGEQ NTSQDLVSEL LLDVEHEN