TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.113.1.1









Ni2+/Co2+ exporter, RcnA/RcnB (Rodrigue et al., 2005; Iwig et al., 2006). RcnB, a small 1 or 2 TMS protein of the DUF3315 or PF11776 family, regulates the activity of RcnA.

Bacteria
Proteobacteria
RcnAB of E. coli
RcnA (P76425)
RcnB (P64534)
*2.A.113.1.2









Ni2+ resistance protein, like NcrC 

Bacteria
Proteobacteria
NcrC homologue of Enterobacter cloaecae (D5CKG5)
*2.A.113.1.3









RcnA homologue
Bacteria
Proteobacteria
RcnA homologue of Ralstonia solanacearum (CAD17703)
*2.A.113.1.4









Urease accessory protein, UreH
Archaea
Euryarchaeota
UreH of Methanocaldococcus jannaschii (Q58492)
*2.A.113.1.5









NiCoT homologue of 6 TMSs with two putative 3 TMS repeats corresponding to TMSs 2-4 and 6-8 in the 8 TMS homologues (B Tsu and DC Yee, unpublished)

Bacteria
Fibrobacteres/Acidobacteria group
NiCoT homologue of Solibacter usitatus
*2.A.113.1.6









NicO homologue of 6 TMSs with TMSs 1-3 corresponding to TMSs 2-4 in the 8 TMS homologues, and TMSs 6-8 corresponding to TMSs 6-8 in the 8 TMS homologues (B Tsu and DC Yee, unpublished).

Bacteria
Planctomycetes
NicO homologue of Rhodopirellula baltica
*2.A.113.1.7









Putative high affinity Ni2+ transporter of 320 aas and 7 TMSs in a 1 3 3 arrangement.

Bacteria
Proteobacteria
Nickel transporter of Starkeya novella
*2.A.113.1.8









Uncharacterized protein of 244 aas and 6 TMSs.

Bacteria
Fusobacteria
UP of Fusobacterium nucleatum
*2.A.113.1.9









Uncharacterized protein of 232 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Oligotropha carboxidovorans
*2.A.113.1.10









Nickel/Cobalt uptake porter, NcrC of 231 aas (Marrero et al. 2007).  This sequence is proably a partial sequence lacking the C-terminal 3-TMS domain as exists in it's closest homologues such as 2.A.113.1.2.

Bacteria
Proteobacteria
NcrC of Serratia marcescens
*2.A.113.1.11









NicO homologue of 236 aas and 6 TMSs.

Bacteria
Firmicutes
NicO homologue of Geobacillus thermoleovorans
*2.A.113.1.12









NicO homologue of 218 aas and 6 TMSs.

Archaea
Euryarchaeota
NicO of Haloferax mediterrainei
*2.A.113.1.13









NicO homologue of 284 aas and 6 TMSs.

Bacteria
Chloroflexi
NicO of Sphaerobacter thermophilus
*2.A.113.1.14









Putative high affinity nickel transporter

Bacteria
Spirochaetes
Putative Ni2+ transporter of Treponema denticola
*2.A.113.2.1









High affinity Nickel transporter of 556 aas and 8 or 9 TMSs in a 1 + 4 +3 or 4 TMS arrangement. TMS 1 is N-terminal. distant from the others. Then there are 4 TMSs followed by a hydrophilic regiion with one peak of very weak hydrophobicity.  This is followed by 3 clear TMSs.

Bacteria
Actinobacteria
NicO family member of Streptomyces griseus
*2.A.113.2.2









Putative Nickel transporter of 597 aas and 7 TMSs in a 1 (N-terminal) + 3 + 3 arrangement.

Bacteria
Actinobacteria
NicO family member in Streptomyces ipomoeae
*2.A.113.2.3









Uncharacterized protein of 488 aas and 7 TMSs in a clear 1 + 3 + 3 arrangement.

Bacteria
Cyanobacteria
UP of Nostoc punctiforme