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2.A.12.1.1
ATP:ADP antiporter (transports ATP and ADP but not dATP, dADP, ddATP or ddADP), Tlc1 (Daugherty et al., 2004)

Accession Number:P19568
Protein Name:TLCA aka Tlc aka TLC1 aka RP053
Length:498
Molecular Weight:56822.00
Species:Rickettsia prowazekii [782]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ATP, ADP

Cross database links:

HEGENOM: HBG586333
RefSeq: NP_220447.1   
Entrez Gene ID: 883599   
BioCyc: RPRO272947:RP053-MONOMER   
KEGG: rpr:RP053   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005471 F:ATP:ADP antiporter activity
GO:0006810 P:transport

References (5)

[1] “Nucleotide sequence of the Rickettsia prowazekii ATP/ADP translocase-encoding gene.”  Williamson L.R.et.al.   2555259
[2] “The genome sequence of Rickettsia prowazekii and the origin of mitochondria.”  Andersson S.G.E.et.al.   9823893
[3] “Identification and initial topological analysis of the Rickettsia prowazekii ATP/ADP translocase.”  Plano G.V.et.al.   1904433
[4] “Rickettsia prowazekii and ATP/ADP translocase. Analysis of gene fusions encoding beta-galactosidase-ATP/ADP translocase fusion proteins.”  Plano G.V.et.al.   2165754
[5] “Membrane topology of the Rickettsia prowazekii ATP/ADP translocase revealed by novel dual pho-lac reporters.”  Alexeyev M.F.et.al.   9917392

External Searches:

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  • CDD Search (Conserved Domain Database)
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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTSKSENYL SELRKIIWPI EQYENKKFLP LAFMMFCILL NYSTLRSIKD GFVVTDIGTE 
61:	SISFLKTYIV LPSAVIAMII YVKLCDILKQ ENVFYVITSF FLGYFALFAF VLYPYPDLVH 
121:	PDHKTIESLS LAYPNFKWFI KIVGKWSFAS FYTIAELWGT MMLSLLFWQF ANQITKIAEA 
181:	KRFYSMFGLL ANLALPVTSV VIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLIILTYRWM 
241:	NKNVLTDPRL YDPALVKEKK TKAKLSFIES LKMIFTSKYV GYIALLIIAY GVSVNLVEGV 
301:	WKSKVKELYP TKEAYTIYMG QFQFYQGWVA IAFMLIGSNI LRKVSWLTAA MITPLMMFIT 
361:	GAAFFSFIFF DSVIAMNLTG ILASSPLTLA VMIGMIQNVL SKGVKYSLFD ATKNMAYIPL 
421:	DKDLRVKGQA AVEVIGGRLG KSGGAIIQST FFILFPVFGF IEATPYFASI FFIIVILWIF 
481:	AVKGLNKEYQ VLVNKNEK