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2.A.12.1.16
ATP:ADP antiporter of 624 aas and 12 TMSs, AATP1. Transports ATP and ADP in a counterflow reaction.  The apparent Km value for ATP was reported to be 28 μM (Neuhaus et al. 1997). In Solanum tuberosum (potato), inhibition of the orthologous AATP1 transporter resulted in greater resistance to the soft rot-causing pathogen, Erwinia carotovora subsp. atroseptica (Linke et al. 2002) and the pathogenic fungus, Alternaria solani (Conrath et al. 2003).

Accession Number:Q39002
Protein Name:TLC1 aka AATP1 aka AT1G80300 aka F5I6.5
Length:624
Molecular Weight:68134.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Plastid1 / Multi-pass membrane protein2
Substrate ATP, ADP

Cross database links:

Genevestigator: Q39002
HEGENOM: HBG586333
RefSeq: NP_178146.1   
Entrez Gene ID: 844370   
KEGG: ath:AT1G80300   

Gene Ontology

GO:0031969 C:chloroplast membrane
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005471 F:ATP:ADP antiporter activity
GO:0005515 F:protein binding
GO:0006810 P:transport

References (5)

[1] “Molecular characterization of an Arabidopsis thaliana cDNA encoding a novel putative adenylate translocator of higher plants.”  Kampfenkel K.et.al.   7589569
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Characterization of a novel eukaryotic ATP/ADP translocator located in the plastid envelope of Arabidopsis thaliana L.”  Neuhaus H.E.et.al.   9025303
[5] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAVIQTRGL LSLPTKPIGV RSQLQPSHGL KQRLFAAKPR NLHGLSLSFN GHKKFQTFEP 
61:	TLHGISISHK ERSTEFICKA EAAAAGDGAV FGEGDSAAVV ASPKIFGVEV ATLKKIIPLG 
121:	LMFFCILFNY TILRDTKDVL VVTAKGSSAE IIPFLKTWVN LPMAIGFMLL YTKLSNVLSK 
181:	KALFYTVIVP FIIYFGAFGF VMYPLSNYIH PEALADKLLT TLGPRFMGPI AILRIWSFCL 
241:	FYVMAELWGS VVVSVLFWGF ANQITTVDEA KKFYPLFGLG ANVALIFSGR TVKYFSNLRK 
301:	NLGPGVDGWA VSLKAMMSIV VGMGLAICLL YWWVNRYVPL PTRSKNKKEK PKMGTMESLK 
361:	FLVSSPYIRD LATLVVAYGI SINLVEVTWK SKLKAQFPSP NEYSAFMGDF STCTGVATFT 
421:	MMLLSQYVFN KYGWGVAAKI TPTVLLLTGV AFFSLILFGG PFAPLVAKLG MTPLLAAVYV 
481:	GALQNIFSKS AKYSLFDPCK EMAYIPLDED TKVKGKAAID VVCNPLGKSG GALIQQFMIL 
541:	SFGSLANSTP YLGMILLVIV TAWLAAAKSL EGQFNSLRSE EELEKEMERA SSVKIPVVSQ 
601:	DESGNGSLGE SPSSSPEKSA PTNL