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2.A.12.1.5
The GTP/GDP transporter, Tlc5 (Audia and Winkler, 2006)

Accession Number:O05962
Protein Name:ADP/ATP translocase 5 aka Tlc5
Length:500
Molecular Weight:57074.00
Species:Rickettsia prowazekii [782]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate GTP, GDP

Cross database links:

HEGENOM: HBG586333
RefSeq: NP_221091.1   
Entrez Gene ID: 883700   
BioCyc: RPRO272947:RP739-MONOMER   
KEGG: rpr:RP739   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005471 F:ATP:ADP antiporter activity
GO:0006810 P:transport

References (2)

[1] “The genome sequence of Rickettsia prowazekii and the origin of mitochondria.”  Andersson S.G.E.et.al.   9823893
[2] “Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence.”  Andersson J.O.et.al.   9274032

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSTSPSRSF KNKFRAAFWP VHNYELGKFI PISALMFCIL FNQNILRILK DSILISEISA 
61:	EIAGFAKVYC VTPVAALFVI IYAKMINHLT FEKIFYYLSA FFISCFILFA FVIYPNIHIF 
121:	HVHPDTLSDW MNKYPHFKWY ISLVGNWGYI VYYSLAELWP NIFYVLLFWQ FTNELTTTEE 
181:	AKRFYTLFSL FGNSSLILVG FLMMNLSSED TIIKKFISIS DSKITLVQVS TTIIAIVAII 
241:	CCLLVRFISK YIFTNPLFYH KTKSSRSTAQ RMGLIKSFKY IVKSKYLWLL LICSAAFGFA 
301:	INLVEAVWKA KIKELYPTVN TYAEFNSLYI LWTGVAIIVM TIIGNNVMRM HNWFVAAVIS 
361:	PVIIMVTGVL FFGLIVFDQQ ILSLFDGAIL MSPLALAVSI GGIQNILAKG TKYSIWDTSR 
421:	EMLYIPLDDE LKTKGKAAVD VISAKVGKSS SGLVQSIIFT LVPNATFTSI SPILMVVFTF 
481:	VCFAWIYAVR KIYFEYQKIA