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2.A.121.1.1
Sulfate transporter, CysZ.  Part of the cysteine biosynthetic pathway; allosterically inhibited by the biosynthetic intermediate, sulfite (Zhang et al. 2014).

Accession Number:P0A6J3
Protein Name:CysZ
Length:253
Molecular Weight:29305.00
Species:Escherichia coli [83333]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Sulfate

Cross database links:

Genevestigator: P0A6J3
EchoBASE: EB0003
EcoGene: EG10003
eggNOG: COG2981
HEGENOM: HBG644223
RefSeq: AP_003007.1    NP_416908.1   
Entrez Gene ID: 946875   
Pfam: PF04401   
BioCyc: EcoCyc:EG10003-MONOMER    ECOL168927:B2413-MONOMER   
KEGG: ecj:JW2406    eco:b2413   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0019344 P:cysteine biosynthetic process
GO:0008272 P:sulfate transport

References (7)

[1] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli.”  Hale C.A.et.al.   9008158
[5] “DNA sequences of the cysK regions of Salmonella typhimurium and Escherichia coli and linkage of the cysK regions to ptsH.”  Byrne C.R.et.al.   3290198
[6] “Phylogeny of metabolic pathways: O-acetylserine sulphydrylase A is homologous to the tryptophan synthase beta subunit.”  Levy S.et.al.   3062311
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVSSFTSAPR SGFYYFAQGW KLVSQPGIRR FVILPLLVNI LLMGGAFWWL FTQLDVWIPT 
61:	LMSYVPDWLQ WLSYLLWPLA VISVLLVFGY FFSTIANWIA APFNGLLAEQ LEARLTGATP 
121:	PDTGIFGIMK DVPRIMKREW QKFAWYLPRA IVLLILYFIP GIGQTVAPVL WFLFSAWMLA 
181:	IQYCDYPFDN HKVPFKEMRT ALRTRKITNM QFGALTSLFT MIPLLNLFIM PVAVCGATAM 
241:	WVDCYRDKHA MWR