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2.A.123.1.4
Stromal cell protein (SCP) homologue, HsSWEET1 or RAG1AP1. Transports glucose and galactose bidirectionally. Present in the ER, Golgi and plasma membrane (Chen et al., 2010).

Accession Number:Q9BRV3
Protein Name:Sugar transporter SWEET1
Length:221
Molecular Weight:25030.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate Sugars

Cross database links:

NOG308353NOG308353
Genevestigator: Q9BRV3 Q9BRV3 Q9BRV3
HEGENOM: HBG716048
Entrez Gene ID: 55974   
Pfam: PF03083   
KEGG: hsa:55974    hsa:55974    hsa:55974   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005634 C:nucleus
GO:0005886 C:plasma membrane
GO:0042947 F:glucoside transmembrane transporter activity
GO:0006310 P:DNA recombination
GO:0045815 P:positive regulation of gene expression, epigenetic
GO:0000139 C:Golgi membrane

References (15)

[1] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”  Hu R.-M.et.al.   10931946
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Sugar transporters for intercellular exchange and nutrition of pathogens.”  Chen L.-Q.et.al.   21107422
[6] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”  Hu R.-M.et.al.   10931946
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Sugar transporters for intercellular exchange and nutrition of pathogens.”  Chen L.-Q.et.al.   21107422
[11] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”  Hu R.-M.et.al.   10931946
[12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[13] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Sugar transporters for intercellular exchange and nutrition of pathogens.”  Chen L.-Q.et.al.   21107422

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT EVNNLGWLSY 
61:	GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ TATLLGVLLL GYGYFWLLVP 
121:	NPEARLQQLG LFCSVFTISM YLSPLADLAK VIQTKSTQCL SYPLTIATLL TSASWCLYGF 
181:	RLRDPYIMVS NFPGIVTSFI RFWLFWKYPQ EQDRNYWLLQ T