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2.A.125.1.2
Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2)

Accession Number:Q9NQ40
Protein Name:Solute carrier family 52, riboflavin transporter, member 3
Length:469
Molecular Weight:50805.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate riboflavin

Cross database links:

Genevestigator: Q9NQ40
eggNOG: NOG326568
HEGENOM: HOG000247012
Entrez Gene ID: 113278   
Pfam: PF06237   
KEGG: hsa:113278   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0032217 F:riboflavin transporter activity
GO:0034605 P:cellular response to heat
GO:0007605 P:sensory perception of sound

References (7)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification and functional characterization of rat riboflavin transporter 2.”  Yamamoto S.et.al.   19122205
[5] “Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain.”  Yao Y.et.al.   20463145
[6] “Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment.”  Bosch A.M.et.al.   21110228
[7] “Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54.”  Green P.et.al.   20206331

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFLMHLLVC VFGMGSWVTI NGLWVELPLL VMELPEGWYL PSYLTVVIQL ANIGPLLVTL 
61:	LHHFRPSCLS EVPIIFTLLG VGTVTCIIFA FLWNMTSWVL DGHHSIAFLV LTFFLALVDC 
121:	TSSVTFLPFM SRLPTYYLTT FFVGEGLSGL LPALVALAQG SGLTTCVNVT EISDSVPSPV 
181:	PTRETDIAQG VPRALVSALP GMEAPLSHLE SRYLPAHFSP LVFFLLLSIM MACCLVAFFV 
241:	LQRQPRCWEA SVEDLLNDQV TLHSIRPREE NDLGPAGTVD SSQGQGYLEE KAAPCCPAHL 
301:	AFIYTLVAFV NALTNGMLPS VQTYSCLSYG PVAYHLAATL SIVANPLASL VSMFLPNRSL 
361:	LFLGVLSVLG TCFGGYNMAM AVMSPCPLLQ GHWGGEVLIV ASWVLFSGCL SYVKVMLGVV 
421:	LRDLSRSALL WCGAAVQLGS LLGALLMFPL VNVLRLFSSA DFCNLHCPA