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2.A.15.1.1
Glycine betaine:Na+ symporter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate)

Accession Number:P54417
Protein Name:OpuD
Length:512
Molecular Weight:56122.00
Species:Bacillus subtilis [1423]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glycine betaine, Na+, Dimethylsulfonioacetate, Dimethylsulfoniopropionate

Cross database links:

HEGENOM: HBG682943
RefSeq: NP_390885.1   
Entrez Gene ID: 937986   
Pfam: PF02028   
KEGG: bsu:BSU30070   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (3)

[1] “Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD.”  Kappes R.et.al.   8752321
[2] “Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.”  Lapidus A.et.al.   9387221
[3] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKHISSVFW IVIAITAAAV LWGVISPDSL QNVSQSAQAF ITDSFGWYYL LVVSLFVGFC 
61:	LFLIFSPIGK IKLGKPDEKP EFGLLSWFAM LFSAGMGIGL VFYGAAEPIS HYAISSPSGE 
121:	TETPQAFRDA LRYTFFHWGL HAWAIYAIVA LCIAYFQFRK GAPGLISSTL SPILGDKVNG 
181:	PIGKAIDCIA VFATVVGVST SLGLGATQIN GGLNYLFGIP NAFIVQLVLI IIVTVLFLLS 
241:	AWSGLGKGIK YLSNTNMVLA GLLMLFMLVV GPTVLIMNSF TDSIGQYIQN IVQMSFRLTP 
301:	NDPEKREWIN SWTIFYWAWW ISWSPFVGIF IARVSRGRTI REFLIGVLVT PCILTFLWFS 
361:	IFGVSAMDLQ QKGAFNVAKL STETMLFGTL DHYPLTMVTS ILALILIAVF FITSADSATF 
421:	VLGMQTSYGS LNPANSVKLS WGIIQSAMAA VLLYSGGLAA LQNTAILAAL PFSIVILLMI 
481:	ASLYQSLSKE RREIKKAEKL DKPRSPRVKK AY