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2.A.15.1.11
Glycine betaine transporter BetL (Glycine betaine-Na(+) symporter)

Accession Number:Q9X4A5
Protein Name:Glycine betaine transporter BetL
Length:507
Molecular Weight:55273.00
Species:Listeria monocytogenes [1639]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glycine betaine, Na+

Cross database links:

HEGENOM: HOG000053240
Pfam: PF02028   
KEGG: lmo:lmo2092   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015199 F:betaine transmembrane transporter activity
GO:0031460 P:glycine betaine transport
GO:0009409 P:response to cold
GO:0006970 P:response to osmotic stress

References (4)

[1] “Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28.”  Sleator R.D.et.al.   10224004
[2] “Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28.”  Sleator R.D.et.al.   11016615
[3] “Transcriptional regulation and posttranslational activity of the betaine transporter BetL in Listeria monocytogenes are controlled by environmental salinity.”  Sleator R.D.et.al.   14645273
[4] “Molecular and physiological analysis of the role of osmolyte transporters BetL, Gbu, and OpuC in growth of Listeria monocytogenes at low temperatures.”  Wemekamp-Kamphuis H.H.et.al.   15128551

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKLTNVFWG SGFLVLLAVL FGAFLPEQFE TFTNHIQKFL TSNFGWYYLI VVAIIIIFCL 
61:	FLVLSPIGSI RLGKPGEEPG YSNKSWFAML FSAGMGIGLV FWGAAEPLSH YAVQAPGGEV 
121:	GTQAAMKDAL RYSFFHWGIS AWSIYAIVAL ALAYFKFRKN APGLISATLY PILGKHAKGP 
181:	IGQLIDIIAV FATVIGVATT LGLGAQQING GLTYLFGVPN NFTVQFTIIV IVTILFMLSA 
241:	MSGLDKGIQL LSNVNIYVAG VLLVLTLILG PTLFIMNNFT NSFGDYLQNI IQMSFQTAPD 
301:	APDARKWIDS WTIFYWAWWL SWSPFVGIFI ARISRGRTIR QFLLGVIVLP ALVSVFWFAV 
361:	FGGSAIFVEQ HGNSGLSSLA TEQVLFGVFN EFPGGMMLSI VAMILIAVFF ITSADSATFV 
421:	LGMQTTGGSL NPPNSVKVTW GLLQAGIASV LLYAGGLTAL QNASIIAAFP FSIVIILMIV 
481:	SLFVSLTREQ EKLGLYVRPK KSQRSQL