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2.A.15.1.4
The high-affinity, proton- or sodium-driven, secondary symporter, BetT.  The cytoplasmic C-terminal domain of plays a role in the regulation of BetT activity; C-terminal truncations cause BetT to be permanently locked in a low-transport-activity mode. (Tøndervik and Strøm 2007).

Accession Number:P0ABC9
Protein Name:High-affinity choline transport protein BetT aka B0314
Length:677
Molecular Weight:75842.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Na+, Choline

Cross database links:

Genevestigator: P0ABC9 P0ABC9
EchoBASE: EB0110 EB0110
EcoGene: EG10112 EG10112
eggNOG: COG1292 COG1292
HEGENOM: HBG682943 HBG682943
RefSeq: AP_000967.1    NP_414848.1   
Entrez Gene ID: 945079   
Pfam: PF02028   
BioCyc: EcoCyc:BETT-MONOMER    ECOL168927:B0314-MONOMER   
KEGG: ecj:JW0306    eco:b0314    ecj:JW0306    eco:b0314   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006950 P:response to stress
GO:0006810 P:transport

References (8)

[1] “DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.”  Lamark T.et.al.   1956285
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[5] “DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.”  Lamark T.et.al.   1956285
[6] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[7] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[8] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTDLSHSREK DKINPVVFYT SAGLILLFSL TTILFRDFSA LWIGRTLDWV SKTFGWYYLL 
61:	AATLYIVFVV CIACSRFGSV KLGPEQSKPE FSLLSWAAML FAAGIGIDLM FFSVAEPVTQ 
121:	YMQPPEGAGQ TIEAARQAMV WTLFHYGLTG WSMYALMGMA LGYFSYRYNL PLTIRSALYP 
181:	IFGKRINGPI GHSVDIAAVI GTIFGIATTL GIGVVQLNYG LSVLFDIPDS MAAKAALIAL 
241:	SVIIATISVT SGVDKGIRVL SELNVALALG LILFVLFMGD TSFLLNALVL NVGDYVNRFM 
301:	GMTLNSFAFD RPVEWMNNWT LFFWAWWVAW SPFVGLFLAR ISRGRTIRQF VLGTLIIPFT 
361:	FTLLWLSVFG NSALYEIIHG GAAFAEEAMV HPERGFYSLL AQYPAFTFSA SVATITGLLF 
421:	YVTSADSGAL VLGNFTSQLK DINSDAPGWL RVFWSVAIGL LTLGMLMTNG ISALQNTTVI 
481:	MGLPFSFVIF FVMAGLYKSL KVEDYRRESA NRDTAPRPLG LQDRLSWKKR LSRLMNYPGT 
541:	RYTKQMMETV CYPAMEEVAQ ELRLRGAYVE LKSLPPEEGQ QLGHLDLLVH MGEEQNFVYQ 
601:	IWPQQYSVPG FTYRARSGKS TYYRLETFLL EGSQGNDLMD YSKEQVITDI LDQYERHLNF 
661:	IHLHREAPGH SVMFPDA