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2.A.15.1.5
Glycine-betaine/proline-betaine:Na+ symporter, BetS

Accession Number:Q92WM0
Protein Name:BetT
Length:706
Molecular Weight:77603.00
Species: [382]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Glycine betaine, Proline betaine, Na+

Cross database links:

HEGENOM: HBG682943 HBG682943
RefSeq: NP_436859.2   
Entrez Gene ID: 1236650   
Pfam: PF02028   
BioCyc: SMEL266834:SMB20333-MONOMER   
KEGG: sme:SM_b20333   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (4)

[1] “The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti.”  Finan T.M.et.al.   11481431
[2] “BetS is a major glycine betaine/proline betaine transporter required for early osmotic adjustment in Sinorhizobium meliloti.”  Boscari A.et.al.   11976294
[3] “The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti.”  Finan T.M.et.al.   11481431
[4] “BetS is a major glycine betaine/proline betaine transporter required for early osmotic adjustment in Sinorhizobium meliloti.”  Boscari A.et.al.   11976294

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQNRVVSCRF TGSTARRATM PEGIRGRSHI LFLVPLSRAE SVGRLHQVQR FKVNLPVFVG 
61:	SVAVIALFVG IGVIAPKRAE SIFSGMQTAI LSGFGWLYLL SVAVFLFSML FLAFSRYGEL 
121:	KLGPDDSEPE FRYLSWIAML FAAGMGIGLM YFAVGEPMTH FASPPEAEPL TIAAQREAMS 
181:	VTFFHWGVHA WAIYSVVGLS LAYFGYRYNL PLTVRSGLYP LLKEGIHGPI GHVVDIFAIC 
241:	GTMFGLATSL GFGILQINSG LNYLLGIPQS IYVQLLLVTV VTAIATISVV TGVEKGVRIL 
301:	SETNLFLAVL LMLFVLVVGP TGTLMRDFVQ NIGLYLDSLV LRTFNIYAYE PRPWIDSWTL 
361:	FYWAWWISWS PFVGMFIARI SRGRTVREFV TAVLFVPAMF TFLWMTVFGN TAIYVDTTIA 
421:	NGELARDVKA DLSVALFQFF EYLPWPAVTS TLAVLLVSIF FVTSSDSGSL VIDTIASGGE 
481:	TATPALQRIF WCSLSGIVAA VLLSTGGLTA LQSATISTAL PFSLVMLILV WSLFVGMRAD 
541:	LARTQSPGSL GPRAYPASGV PWQRRLAMTL STPDRRAVEK FLQASVLPAL EAVARELTRR 
601:	SRPASVGRDA ETGALTLTVP AEGHRDFVYG VQMSEHKLPA FTAYDATVAD VRYEARTFFS 
661:	DGSRGYDIMG MADNQIINDV LFQFERYTGF VRSPESSLLA TSPEER