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2.A.16.1.1
Tellurite resistance protein, TehA.  Encoded in an operon with the gene for a tellurite S-adenosylmethionine-dependent methyl transferase.  Together they confer tellurite resistance (Moraes and Reithmeier 2012).

Accession Number:P25396
Protein Name:TehA aka B1429
Length:330
Molecular Weight:35932.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Tellurite

Cross database links:

Genevestigator: P25396
EchoBASE: EB1829
EcoGene: EG11883
eggNOG: COG1275
HEGENOM: HBG296909
RefSeq: AP_002052.1    NP_415946.1   
Entrez Gene ID: 945852   
Pfam: PF03595   
BioCyc: EcoCyc:TEHA-MONOMER    ECOL168927:B1429-MONOMER   
KEGG: ecj:JW1425    eco:b1429   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0046690 P:response to tellurium ion
GO:0055085 P:transmembrane transport

References (6)

[1] “Nucleotide sequence and overexpression of the tellurite-resistance determinant from the IncHII plasmid pHH1508a.”  Walter E.G.et.al.   2060788
[2] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.”  Aiba H.et.al.   9097039
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Location of a potassium tellurite resistance operon (tehA tehB) within the terminus of Escherichia coli K-12.”  Taylor D.E.et.al.   8169225
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQSDKVLNLP AGYFGIVLGT IGMGFAWRYA SQVWQVSHWL GDGLVILAMI IWGLLTSAFI 
61:	ARLIRFPHSV LAEVRHPVLS SFVSLFPATT MLVAIGFVPW FRPLAVCLFS FGVVVQLAYA 
121:	AWQTAGLWRG SHPEEATTPG LYLPTVANNF ISAMACGALG YTDAGLVFLG AGVFSWLSLE 
181:	PVILQRLRSS GELPTALRTS LGIQLAPALV ACSAWLSVNG GEGDTLAKML FGYGLLQLLF 
241:	MLRLMPWYLS QPFNASFWSF SFGVSALATT GLHLGSGSDN GFFHTLAVPL FIFTNFIIAI 
301:	LLIRTFALLM QGKLLVRTER AVLMKAEDKE