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2.A.16.2.1
Mae1 malate transport protein

Accession Number:P50537
Protein Name:Mae1 or SPAPB8E5.03
Length:438
Molecular Weight:49304.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate malate

Cross database links:

eggNOG: fuNOG06451
HEGENOM: HBG208724
RefSeq: NP_594777.1   
Entrez Gene ID: 2543334   
Pfam: PF03595   
KEGG: spo:SPAPB8E5.03   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0015140 F:malate transmembrane transporter activity
GO:0015141 F:succinate transmembrane transporter activity
GO:0071423 P:malate transmembrane transport
GO:0071422 P:succinate transmembrane transport

References (3)

[1] “The mae1 gene of Schizosaccharomyces pombe encodes a permease for malate and other C4 dicarboxylic acids.”  Grobler J.et.al.   8750236
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[3] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGELKEILKQ RYHELLDWNV KAPHVPLSQR LKHFTWSWFA CTMATGGVGL IIGSFPFRFY 
61:	GLNTIGKIVY ILQIFLFSLF GSCMLFRFIK YPSTIKDSWN HHLEKLFIAT CLLSISTFID 
121:	MLAIYAYPDT GEWMVWVIRI LYYIYVAVSF IYCVMAFFTI FNNHVYTIET ASPAWILPIF 
181:	PPMICGVIAG AVNSTQPAHQ LKNMVIFGIL FQGLGFWVYL LLFAVNVLRF FTVGLAKPQD 
241:	RPGMFMFVGP PAFSGLALIN IARGAMGSRP YIFVGANSSE YLGFVSTFMA IFIWGLAAWC 
301:	YCLAMVSFLA GFFTRAPLKF ACGWFAFIFP NVGFVNCTIE IGKMIDSKAF QMFGHIIGVI 
361:	LCIQWILLMY LMVRAFLVND LCYPGKDEDA HPPPKPNTGV LNPTFPPEKA PASLEKVDTH 
421:	VTSTGGESDP PSSEHESV