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2.A.16.2.2
The ATP-dependent subtelomeric helicase, RecQ (2100 aas with a 5 TMS N-terminal domain (residues 43-210). 94% identical to 2.A.16.2.1 (malate transporter) of the same species.

Accession Number:Q5EAK4
Protein Name:Sub-telomeric helicase RecQ homolog 1
Length:2100
Molecular Weight:239993.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate malate

Cross database links:

HEGENOM: HBG677052
RefSeq: NP_595040.1   
Entrez Gene ID: 5802989   
Pfam: PF03595    PF00270    PF00271   
KEGG: spo:SPAC212.11a   

Gene Ontology

GO:0000781 C:chromosome, telomeric region
GO:0016021 C:integral to membrane
GO:0005634 C:nucleus
GO:0005524 F:ATP binding
GO:0043140 F:ATP-dependent 3'-5' DNA helicase activity
GO:0003676 F:nucleic acid binding
GO:0008270 F:zinc ion binding
GO:0000722 P:telomere maintenance via recombination
GO:0055085 P:transmembrane transport

References (2)

[1] “Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.”  Mandell J.G.et.al.   15591066
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MATGGVGLII GSFPFRFYGL NTIGKIVYIL QIVLLTLFGS CMLFRFIKYP STIKDSWNHH 
61:	LEKLFIATCL LSLSTFIDML AIYAYADTGE WMVWVIRILY YIFVAVAFIY CVSAFFTIFN 
121:	NHVYTIETAS PAWILPIFPP MICGVIAGAV NATQPARQLK NMVIFGILFF FFFFFFHIST 
181:	AMVVASEIAK VASKTARDIA GCFTCQCGTQ FDNVERIVQH FKECRYRDET CKDDDIVVYE 
241:	PSSFVQDEKK DKPIIVEAAS EATSEEACNS SKERQLPALS ALSALSTLTT SANDDLWTAR 
301:	LIWQSTNDTK LDNSPSSNYT DLNHKLANYG LSILSIHALM CVECECLLNV IHTAQHMQIV 
361:	HKLELNEDLL WFQELRTLKL KSPTNVLQTH SSQTHVYPYI RGLPVLLNGY ECVPCTKNGT 
421:	GFVHAIMDTF RHHVRRTHGK VIKLENCIRR TALQTVKNKY AQRCQFFKVD YVPLNGGEEE 
481:	EEEEGEEKED AQNIKERMVD FCFSKFMEKN QQRREQQDKG ENKKRQDDVD QATDNNTNTI 
541:	LEDDEKDNDE EEEEEIVNAR EKNLLNQQFN WTAIVKKLGE NWDQLVRFEY TNGIVTLDTI 
601:	VNQLIRYYYR GFRHLSGMTM GMRRMFTQGG SYSAQERGLC RLEQKDTVVR YAQSAALYLI 
661:	FLLRRPSADS GIRRHLEAMC GATVERKEGG SNSSSNISNV ANFDSAEDDN DNDNDNDRDS 
721:	NNNNNNNNTN TDDDDKLAYL ELHEALKLAF LQQYDFSKNV QDLEIMEFLA CMSLHKDGTS 
781:	KYAYEISACF APLIYTCRLV AACELQRLID EKQIDLLSIP SFQTAGSIAY AHVFCFITLG 
841:	QRNLYDVLYE TQKVVRDIIR TEGYANTLQG LSPSTVLFQP RSNSMYPCIG DAFNNMVRLD 
901:	LSELTALYEG MFAKVQDLLK ELCFDMNVEK LLPISLLRSI GDDINNSKLG YSFFKESIEI 
961:	RSSHSVLLRT ILKNSELCHR FFPSMSKKDL TKLFGGVSDQ QRNECDNYSN HYNDNSNDND 
1021:	NDVFLKLHWS KSAIKKYETK ASIFNELLFC LVYISAGQPA RAQEMVYWTL RNGKYKTREL 
1081:	YLMFGRLMIY SRYDKTRNMK FAEKPIPRFL SEPLSILALR YYVLVRPLEA LMKYVTTADR 
1141:	SKVAVYLDFM FVIAGERLQR DLPYRIFPKA TYQCIQKPLG FRNYRHIAHY FKEKNIEEEM 
1201:	TRESYFDLQA GHTRNTALYI YGRTMDNLHY LPSDYFANFF RASYKWQELL QIRDNPTHGL 
1261:	LVETKHPFIK RVDQLEEALN EKLARLVGEQ MVEGDKEKDK TNEEKNKDEV KAEMTQPVVN 
1321:	QDSHDLQDQL ATTPTAPTAF HYRPGLLQPS QTSVQHCCWA LSQYYGLEAK FRSLKQFQSV 
1381:	YFSLLNRMNL ITVLPTGGGK SLSFLIPALI EKKRQTPGKV MNMVTLVLVP MMSLRQDMML 
1441:	RVNEKGLLVC SGNWTAFKDV RLTLETQLPD LFILTYESAL TNSGLRFFES LATLGRLARV 
1501:	VIDEAHLLLT SGAWRTALSR ASRLSGLYAP LHLLSATFPR QLEMVARQTF CTNFYVLRET 
1561:	STARENIFYF LHPYDNTEFL LDLRTLMKRT KVFEGDGRAI IFCRTKKDVE YIHRRLHQSD 
1621:	LFAHTHVTIY TGDVSDEERQ MNFDAFRNAN GKTRIMIATK AFGLGINYMG VRLVVHYGLP 
1681:	ASSMDYVQET GRAGRDGKYA IAALFYEKYD STWSSYVEDS MKNFLNDNTM CVRSFLASEM 
1741:	DGECVCCASF ANCVYCSRCS DSLLGEESTV STMYGVKPTL PETPKPAIAT HSRYNASFSS 
1801:	SPPPQPGNSS GMSAMNTNTT STTPVSLSEL SEITLFPSSV SPTWKKSFGN ANTNLKYGLE 
1861:	DMSLSHRRGH KRTYDEHLNN VQQGVNHDMN RVHGSVGGMS GIVGIGIGIG DGDGDGDVDS 
1921:	RTIHFAEYKS RVQAVKKQWV DSTDISAQLE RFFRVYKDEC LSCTLGNPDT EIRAHTGKAC 
1981:	PVRLSTCYKC GKADHNLREC KLRIRFQGLC LFCGLTKFEH ADSDMAYTSD CRSWARKANL 
2041:	ISLVYYAWNN VQYRRTIADK FLQGDVRDQA FYGFVCCSTT TNSAFVLVIH YLLSDVLQIM