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2.A.16.5.1
The plant guard cell S (Slow)-type anion channel, SLAC1 (based on activation kinetics of anion channel currents in response to voltage changes); functions in stomatal signalling, controls turgor pressure, and regulates the exchange of water and CO2 (Chen et al. 2010). Also called carbon dioxide insensitive (CDI3) and ozone sensitive (OZS1) (Kollist et al., 2011). Heterotrimeric G proteins regulate guard cell ion channels (Zhang, 2011). Evolutionary studies have been reported (Dreyer et al. 2012). The transmembrane region of guard cell SLAC1 channels detect CO2 signals via an abscisic acid (ABA)-independent pathway (Yamamoto et al. 2016).  SLAC1 is activated by the protein kinase OST1 (OPEN STOMATA 1), the Ca2+-dependent protein kinases (CPKs), the GHR1 (GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1) transmembrane receptor-like protein (TC# 1.A.87.2.8), or the PYL5 abscisic acid (ABA) receptor (Q9FLB1)  (Wang et al. 2017).

Accession Number:Q9LD83
Protein Name:At1g12480
Length:556
Molecular Weight:63235.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate anions

Cross database links:

Genevestigator: Q9LD83
eggNOG: NOG145806
HEGENOM: HBG319707
RefSeq: NP_563909.1   
Entrez Gene ID: 837805   
Pfam: PF03595   
KEGG: ath:AT1G12480   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006820 P:anion transport
GO:0006873 P:cellular ion homeostasis
GO:0050891 P:multicellular organismal water homeostasis
GO:0009737 P:response to abscisic acid stimulus
GO:0010037 P:response to carbon dioxide
GO:0009270 P:response to humidity
GO:0010193 P:response to ozone
GO:0010118 P:stomatal movement
GO:0055085 P:transmembrane transport

References (1)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERKQSNAHS TFADINEVED EAEQELQQQE NNNNKRFSGN RGPNRGKQRP FRGFSRQVSL 
61:	ETGFSVLNRE SRERDDKKSL PRSGRSFGGF ESGGIINGGD GRKTDFSMFR TKSTLSKQKS 
121:	LLPSIIRERD IENSLRTEDG ETKDDSINEN VSAGRYFAAL RGPELDEVKD NEDILLPKEE 
181:	QWPFLLRFPI GCFGICLGLS SQAVLWLALA KSPATNFLHI TPLINLVVWL FSLVVLVSVS 
241:	FTYILKCIFY FEAVKREYFH PVRVNFFFAP WVVCMFLAIS VPPMFSPNRK YLHPAIWCVF 
301:	MGPYFFLELK IYGQWLSGGK RRLCKVANPS SHLSVVGNFV GAILASKVGW DEVAKFLWAV 
361:	GFAHYLVVFV TLYQRLPTSE ALPKELHPVY SMFIAAPSAA SIAWNTIYGQ FDGCSRTCFF 
421:	IALFLYISLV ARINFFTGFK FSVAWWSYTF PMTTASVATI KYAEAVPGYP SRALALTLSF 
481:	ISTAMVCVLF VSTLLHAFVW QTLFPNDLAI AITKRKLTRE KKPFKRAYDL KRWTKQALAK 
541:	KISAEKDFEA EEESHH