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2.A.16.5.2
Slow anion channel homologue-3, SLAH3; nitrate is both a substrate and a gate opener (Geiger et al. 2011). Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis (Negi et al. 2008). Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity. Functions as an essential negative regulator of inward potassium channels in guard cells. Essential for the efficient stomatal closure and opening in guard cells (Zhang et al. 2016). The plasma membrane Glycine soja (soy bean) GsSLAH3 protein contains ten TMSs. GsSLAH3 expression is induced by NaHCO3 treatment, suggesting an involvement to alkaline stress, and ectopic expression of GsSLAH3 in yeast increased sensitivity to alkali treatment (Duan et al. 2017). Overexpression of GsSLAH3 in Arabidopsis thaliana enhanced alkaline tolerance during germination, seedling and adult stages. Transgenic lines improved plant tolerance to KHCO3 rather than high pH treatment. Overexpressing lines accumulated more NO3- than wild type (Duan et al. 2017).  

Accession Number:Q9FLV9
Protein Name:S-type anion channel SLAH3
Length:635
Molecular Weight:72339.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate anions

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEKPNYVIQ VEEELPTLLR KATTEEMVGF DNYKENGHPF PHSISRFHPS HASTTTLNGQ 
61:	ETSRSIDTME AHHHNYNETT PWTHQRKPSI SMPTSPNVLM ISDPTTSLSS ENHKNSGSTG 
121:	KSVKFLSQPM TKVSSLYIES GNGDDDRRQS HDNHHHHLHR QHQSGHHQNQ NQAANKLKDN 
181:	RYNSFKTWSG KLERQFTRKP ASVEPEAPNR NNQNLNTNEA MPVDRYYDAL EGPELETLRP 
241:	QEEIVLPNDK KWPFLLRYPI STFGMCLGVS SQAIMWKTLA TAEPTKFLHV PLWINQGLWF 
301:	ISVALILTIA TIYLLKIILF FEAVRREYYH PIRINFFFAP FISLLFLALG VPPSIITDLP 
361:	HFLWYLLMFP FICLELKIYG QWMSGGQRRL SRVANPTNHL SVVGNFVGAL LGASMGLREG 
421:	PIFFYAVGMA HYLVLFVTLY QRLPTNETLP KDLHPVFFLF VAAPSVASMA WAKVTGSFDY 
481:	GSKVCYFIAI FLYFSLAVRI NFFRGIKFSL SWWAYTFPMT GAAIATIRYA TVVKSTMTQI 
541:	MCVVLCAIAT LVVFALLVTT IIHAFVLRDL FPNDLAIAIS NRPRPKQNSQ HRWLDQLRNV 
601:	SSENIENYLK FTDSDSSQSN DVEACNGKTQ ESDSS