TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.17.1.3
The dipeptide/tripeptide:H+ symport permease, DtpB (YhiP) (transports glycyl-sarcosine (Gly-Sar) with low affinity (6mM) and the toxic dipeptide, alafosfalin (Harder et al., 2008)

Accession Number:P36837
Protein Name:DtpB
Length:489
Molecular Weight:53575.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate dipeptides, tripeptides, H+, Glycyl-sarcosine, Alafosfalin

Cross database links:

Genevestigator: P36837
EchoBASE: EB2144
EcoGene: EG12232
eggNOG: COG3104
HEGENOM: HBG586603
DIP: DIP-12369N
RefSeq: AP_004297.1    NP_417953.1   
Entrez Gene ID: 948006   
Pfam: PF00854   
BioCyc: EcoCyc:YHIP-MONOMER    ECOL168927:B3496-MONOMER   
KEGG: ecj:JW3463    eco:b3496   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0042936 F:dipeptide transporter activity
GO:0015293 F:symporter activity
GO:0042937 F:tripeptide transporter activity
GO:0042938 P:dipeptide transport
GO:0042939 P:tripeptide transport

References (4)

[1] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNTTTPMGML QQPRPFFMIF FVELWERFGY YGVQGVLAVF FVKQLGFSQE QAFVTFGAFA 
61:	ALVYGLISIG GYVGDHLLGT KRTIVLGALV LAIGYFMTGM SLLKPDLIFI ALGTIAVGNG 
121:	LFKANPASLL SKCYPPKDPR LDGAFTLFYM SINIGSLIAL SLAPVIADRF GYSVTYNLCG 
181:	AGLIIALLVY IACRGMVKDI GSEPDFRPMS FSKLLYVLLG SVVMIFVCAW LMHNVEVANL 
241:	VLIVLSIVVT IIFFRQAFKL DKTGRNKMFV AFVLMLEAVV FYILYAQMPT SLNFFAINNV 
301:	HHEILGFSIN PVSFQALNPF WVVLASPILA GIYTHLGNKG KDLSMPMKFT LGMFMCSLGF 
361:	LTAAAAGMWF ADAQGLTSPW FIVLVYLFQS LGELFISALG LAMIAALVPQ HLMGFILGMW 
421:	FLTQAAAFLL GGYVATFTAV PDNITDPLET LPVYTNVFGK IGLVTLGVAV VMLLMVPWLK 
481:	RMIATPESH