TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.17.1.4
DtpD (YbgH) peptide transporter.  A projection structure at 19 Å resolution and a high resolution x-ray structure are available; Casagrande et al., 2009; Zhao et al. 2014). Glu21 is the only conserved proton-titratable amino acyl residue (among POTs) that is located in the central cavity, and it is critical for in vivo transport (Zhao et al. 2014).

Accession Number:P75742
Protein Name:Inner membrane transporter ybgH
Length:493
Molecular Weight:54159.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

Genevestigator: P75742
EchoBASE: EB3088
EcoGene: EG13304
eggNOG: COG3104
HEGENOM: HBG586603
DIP: DIP-11394N
RefSeq: AP_001347.1    NP_415237.1   
Entrez Gene ID: 947368   
Pfam: PF00854   
BioCyc: EcoCyc:B0709-MONOMER    ECOL168927:B0709-MONOMER   
KEGG: ecj:JW0699    eco:b0709   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0042936 F:dipeptide transporter activity
GO:0042938 P:dipeptide transport

References (4)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
Structure:
4Q65     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNKHASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYNDTHAYEL FSAYCSLVYV 
61:	TPILGGFLAD KVLGNRMAVM LGALLMAIGH VVLGASEIHP SFLYLSLAII VCGYGLFKSN 
121:	VSCLLGELYE PTDPRRDGGF SLMYAAGNVG SIIAPIACGY AQEEYSWAMG FGLAAVGMIA 
181:	GLVIFLCGNR HFTHTRGVNK KVLRATNFLL PNWGWLLVLL VATPALITIL FWKEWSVYAL 
241:	IVATIIGLGV LAKIYRKAEN QKQRKELGLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN 
301:	RDMFGYTVPT AMFQSINAFA VMLCGVFLAW VVKESVAGNR TVRIWGKFAL GLGLMSAGFC 
361:	ILTLSARWSA MYGHSSLPLM VLGLAVMGFA ELFIDPVAMS QITRIEIPGV TGVLTGIYML 
421:	LSGAIANYLA GVIADQTSQA SFDASGAINY SINAYIEVFD QITWGALACV GLVLMIWLYQ 
481:	ALKFRNRALA LES