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2.A.17.1.6
POT famiy di- and tri-peptide porter, DtpT. 3-d structures (PDB:24APS; 5MMT: 5D58' 5D59) are available for an inward open conformation. A hinge-like movement in the C-terminal half facilitates opening of an intracellular gate controlling access to a central peptide binding site. Salt bridges may orchestrate alternating access (Solcan et al., 2012; Quistgaard et al. 2017).

Accession Number:Q5M4H8
Protein Name:Di-or tripeptide:H+ symporter
Length:483
Molecular Weight:52749.00
Species:Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) [264199]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate dipeptides, tripeptides

Cross database links:

eggNOG: COG3104
HEGENOM: HOG000243451
Entrez Gene ID: 3164310   
Pfam: PF00854   
KEGG: stl:stu0970   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015197 F:peptide transporter activity
GO:0006857 P:oligopeptide transport

References (1)

[1] “Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus.”  Bolotin A.et.al.   15543133
Structure:
4APS   4D2B   4D2C   4D2D   4XNI   4XNJ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEDKGKTFFG QPLGLSTLFM TEMWERFSYY GMRAILLYYM WFLISTGDLH ITRATAASIM 
61:	AIYASMVYLS GTIGGFVADR IIGARPAVFW GGVLIMLGHI VLALPFGASA LFGSIILIII 
121:	GTGFLKPNVS TLVGTLYDEH DRRRDAGFSI FVFGINLGAF IAPLIVGAAQ EAAGYHVAFS 
181:	LAAIGMFIGL LVYYFGGKKT LDPHYLRPTD PLAPEEVKPL LVKVSLAVAG FIAIIVVMNL 
241:	VGWNSLPAYI NLLTIVAIAI PVFYFAWMIS SVKVTSTEHL RVVSYIPLFI AAVLFWAIEE 
301:	QGSVVLATFA AERVDSSWFP VSWFQSLNPL FIMLYTPFFA WLWTAWKKNQ PSSPTKFAVG 
361:	LMFAGLSFLL MAIPGALYGT SGKVSPLWLV GSWALVILGE MLISPVGLSV TTKLAPKAFN 
421:	SQMMSMWFLS SSVGSALNAQ LVTLYNAKSE VAYFSYFGLG SVVLGIVLVF LSKRIQGLMQ 
481:	GVE