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2.A.17.1.7
Peptide uptake transporter of 496 aas, POT.  The 3-d structure has been determined to 1.9Å resolution leading to a proposed mechanism (Doki et al. 2013).  Glu310 first may bind the carboxyl group of the peptide substrate. Then deprotonation of Glu310 in the inward open state triggers the release of the bound peptide toward the intracellular space, and salt bridge formation between Glu310 and Arg43 induces the transition state to the occluded conformation.

Accession Number:Q5KYD1
Protein Name:Di-tripeptide ABC transporter (Permease)
Length:496
Molecular Weight:53457.00
Species:Geobacillus kaustophilus (strain HTA426) [235909]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

Structure:
4IKV   4IKW   4IKX   4IKY   4IKZ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASIDKQQIA ASVPQRGFFG HPKGLFTLFF TEFWERFSYY GMRAILVYYM YYEVSKGGLG 
61:	LDEHLALAIM SIYGALVYMS GIIGGWLADR VFGTSRAVFY GGLLIMAGHI ALAIPGGVAA 
121:	LFVSMALIVL GTGLLKPNVS SIVGDMYKPG DDRRDAGFSI FYMGINLGAF LAPLVVGTAG 
181:	MKYNFHLGFG LAAVGMFLGL VVFVATRKKN LGLAGTYVPN PLTPAEKKKA AAIMAVGAVV 
241:	IAVLLAILIP NGWFTVETFI SLVGILGIII PIIYFVVMYR SPKTTAEERS RVIAYIPLFV 
301:	ASAMFWAIQE QGSTILANYA DKRTQLDVAG IHLSPAWFQS LNPLFIIILA PVFAWMWVKL 
361:	GKRQPTIPQK FALGLLFAGL SFIVILVPGH LSGGGLVHPI WLVLSYFIVV LGELCLSPVG 
421:	LSATTKLAPA AFSAQTMSLW FLSNAAAQAI NAQLVRFYTP ENETAYFGTI GGAALVLGLI 
481:	LLAIAPRIGR LMKGIR