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2.A.17.3.11
Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) present in immune cells (Verri et al. 2016).

Accession Number:Q8N697
Protein Name:Solute carrier family 15 member 4
Length:577
Molecular Weight:62034.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate peptides, Histidine

Cross database links:

Genevestigator: Q8N697
eggNOG: COG3104
HEGENOM: HOG000143436
Entrez Gene ID: 121260   
Pfam: PF00854   
KEGG: hsa:121260   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0005290 F:L-histidine transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006811 P:ion transport
GO:0006857 P:oligopeptide transport
GO:0015031 P:protein transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Large-scale cDNA transfection screening for genes related to cancer development and progression.”  Wan D.et.al.   15498874
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics.”  Botka C.W.et.al.   11741232
[5] “Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues.”  Herrera-Ruiz D.et.al.   11741260
[6] “The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells.”  Bhardwaj R.K.et.al.   16289537

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA FYGITSNLVL 
61:	FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL GRARAILLSL ALYLLGMLAF 
121:	PLLAAPATRA ALCGSARLLN CTAPGPDAAA RCCSPATFAG LVLVGLGVAT VKANITPFGA 
181:	DQVKDRGPEA TRRFFNWFYW SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF 
241:	LCGQSVFITK PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK 
301:	MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR IPEISNITTT 
361:	PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS SLKRIAVGMF FVMCSAFAAG 
421:	ILESKRLNLV KEKTINQTIG NVVYHAADLS LWWQVPQYLL IGISEIFASI AGLEFAYSAA 
481:	PKSMQSAIMG LFFFFSGVGS FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA 
541:	AIQGATLLLF LIISVKYDHH RDHQRSRANG VPTSRRA