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2.A.17.3.9
solute carrier family 15, member 3, di- and tri-peptide uptake transporter in immune cells (Verri et al. 2016).

Accession Number:Q8IY34
Protein Name:Solute carrier family 15 member 3
Length:581
Molecular Weight:63560.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Lysosome membrane1 / Multi-pass membrane protein2
Substrate dipeptides, tripeptides

Cross database links:

Genevestigator: Q8IY34 Q8IY34
eggNOG: COG3104 COG3104
HEGENOM: HOG000143436 HOG000143436
Entrez Gene ID: 51296   
Pfam: PF00854   
KEGG: hsa:51296    hsa:51296   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0015293 F:symporter activity
GO:0006811 P:ion transport
GO:0006857 P:oligopeptide transport
GO:0015031 P:protein transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319
[4] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL 
61:	NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA 
121:	TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT 
181:	SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA 
241:	FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 
301:	ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA 
361:	LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT 
421:	SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL 
481:	EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL 
541:	YFFLLAGIQA VTALLFVWIA GRYERASQGP ASHSRFSRDR G