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2.A.17.4.3
High affinity oligopeptide transporter, CPTA. It transports di-, tri- and tetra peptides with low specificity. Neuropeptides (FMRF-amide and N-acetyl-Asp-Glu) are also transported (Fei et al. 1998).

Accession Number:Q17758
Protein Name:Peptide transporter family 2
Length:785
Molecular Weight:87567.00
Species: [6239]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2 / Lumenal side3
Substrate peptides

Cross database links:

eggNOG: meNOG04856
HEGENOM: HBG447142
RefSeq: NP_502002.1   
Entrez Gene ID: 177973   
Pfam: PF00854   
KEGG: cel:C06G8.2   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015198 F:oligopeptide transporter activity
GO:0006857 P:oligopeptide transport
GO:0015031 P:protein transport

References (5)

[1] “Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression.”  Fei Y.-J.et.al.   9601088
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span.”  Nehrke K.et.al.   12939266
[4] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667
[5] “Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2.”  Husken K.et.al.   18452552

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGASHLHDDP RPGSPVDHQP TTWGGIIKKW PKQTFLIVGN ELCERFSFYG MRAVLTLYFF 
61:	NILNFSQSFS TVLFHAFTVI CYSSPLLGSI LADGYIGKFW TIFFISIFYA CGQILLAFSS 
121:	IAPSGSSHHP LLDLLGLLIV GLGTGGIKPC VSAFGGDQFP AHYTRMISLF FSMFYFSINA 
181:	GSLISMWLTP YFRSMSCFGH DSCYPLAFGI PAILMIVATL VFMAGSFWYK KVPPKENIIF 
241:	KVIGTITTAL RKKASSSSTH QRSHWLEYSL DGHDCALSTE CKNLHGNCAQ RRYIEDIKRL 
301:	FRVIVMMIPV PMFWALYDQQ GSTWVLQAVG MDAKVFGFEI LPDQMGVLNA FLILFFIPIF 
361:	QSIVYPTIEK LGFQMTMLRK MAGGGILTAV SFFVCGIVQL FVNPTLPYIP MANEAHLTII 
421:	NTIPSCDFNV LIDSREPFDL LRKSGIAPDD SVRKPISFTG DDFFQPNITF DNLAPNCPKF 
481:	TAEPMLAPAT SYVLTLSPNG WAYNAVRPEK PKSGKGELSM GLNLIVPCDK IPSNVTWEQC 
541:	NGTEGYSGAI ALCKVESDVI TDNNNVCDPT AKGKFYVLSN ANPLDVHDFS KKSTVTAFGR 
601:	TYSPIEMKPG TYRLFYTDDS RTHFTPLNLP PVQQDHMGGQ YLITVSTRSK NDSEVLATTE 
661:	SLVSYNRVSI LWQIPQYVIL TAGEVLFSIT GLEFAYTEAS PQLKSVVQAL WLFTTAIGDL 
721:	IVVVIFMLNI FSDVAVQMFV FGGIMLFVIF VFILLAVFYY EYADYSNESE VLTEKMIVDD 
781:	DHTRI