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2.A.17.4.4
The renal brush-border electrogenic, proton-coupled, broad specificity, high affinity, peptide transporter, PepT2 (Rubio-Aliaga et al., 2000). It is competitively inhibited by L-4,4'-Biphenylalanyl-L-Proline (Bip-Pro) with ~10-20┬ÁM affinity. Inhibitor/substrates includes cefadroxil, Ala-4-nitroanilide and delta-aminolevulinic acid (Knutter et al., 2007).

Accession Number:Q9ES07
Protein Name:Solute carrier family 15 member 2
Length:729
Molecular Weight:81632.00
Species:Mus musculus [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

Genevestigator: Q9ES07
Pfam: PF00854   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015334 F:high affinity oligopeptide transporter acti...
GO:0015293 F:symporter activity
GO:0015031 P:protein transport

References (1)

[1] “Cloning and characterization of the gene encoding the mouse peptide transporter PEPT2.”  Rubio-Aliaga I.et.al.   11027540

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNPFQKNESK ETLFSPVSTE EMLPGPPSPP KKSTPKLFGS SYPLSIAFIV VNEFCERFSY 
61:	YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 
121:	YVLGHVFKSL GAIPILGGKM LHTILSLVGL SLIALGTGGI KPCVAAFGGD QFEEEHAEAR 
181:	TRYFSVFYLS INAGSLISTF ITPMLRGDVK CFGEDCYALA FGIPGLLMVL ALVVFAMGSK 
241:	MYRKPPPEGN IVAQVTKCIW FAICNRFRNR SEDIPKRQHW LDWAAEKYPK HLIMDVKALT 
301:	RILFLYIPLP MFWALLDQQG SRWTLQANKM DGDLGFFVLQ PDQMQVLNPF LVLVFIPLFD 
361:	LVIYRLISKC GVNFSSLRKM AVGMILACLA FAVAALVEIK INGMIHPQPA SQEIFLQVLN 
421:	LADGEIEVTV QGNRNNPLLV ESISSFQNTT HYSKLRLETK SQDLHFHLKY NNLSVHNEYS 
481:	VEEKNCYQLV VHENGESLSS MLVKDTGIKP ANGMTAIRFI NTLHKDMNIS LDANAPLSVG 
541:	KDYGVSEYRT VQRGKYPAVH CETEDNVFSL NLGQLDFGTT YLFVITNITN RGLQAWKAED 
601:	IPANKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTVAVGNIIV 
661:	LIVAQFSGLV QWAEFVLFSC LLLVVCLIFS VMGYYYVPLK SEGIHEATEK QIPHIQGNMI 
721:	NLETKNTRL