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2.A.17.4.7
Di-/Tri-peptide porter. 3-d structure (PDB: 2XUT) known revealing a probable alternating access mechanism of transport (Newstead et al., 2011).  A second structure shows the protein in an inward open conformation with the peptidommetic, alafosfalin, bound (Guettou et al. 2013).

Accession Number:Q8EKT7
Protein Name:Proton/peptide symporter family protein
Length:516
Molecular Weight:56705.00
Species:Shewanella oneidensis (strain MR-1) [211586]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate dipeptides, tripeptides

Cross database links:

HEGENOM: HOG000285186
Entrez Gene ID: 1167900   
Pfam: PF00854   
KEGG: son:SO_0002   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015197 F:peptide transporter activity
GO:0006857 P:oligopeptide transport

References (2)

[1] “Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis.”  Heidelberg J.F.et.al.   12368813
[2] “Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.”  Newstead S.et.al.   21131908
Structure:
2XUT   4UVM     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTTPVDAPKW PRQIPYIIAS EACERFSFYG MRNILTPFLM TALLLSIPEE LRGAVAKDVF 
61:	HSFVIGVYFF PLLGGWIADR FFGKYNTILW LSLIYCVGHA FLAIFEHSVQ GFYTGLFLIA 
121:	LGSGGIKPLV SSFMGDQFDQ SNKSLAQKAF DMFYFTINFG SFFASLSMPL LLKNFGAAVA 
181:	FGIPGVLMFV ATVFFWLGRK RYIHMPPEPK DPHGFLPVIR SALLTKVEGK GNIGLVLALI 
241:	GGVSAAYALV NIPTLGIVAG LCCAMVLVMG FVGAGASLQL ERARKSHPDA AVDGVRSVLR 
301:	ILVLFALVTP FWSLFDQKAS TWILQANDMV KPQWFEPAMM QALNPLLVML LIPFNNFVLY 
361:	PAIERMGVKL TALRKMGAGI AITGLSWIVV GTIQLMMDGG SALSIFWQIL PYALLTFGEV 
421:	LVSATGLEFA YSQAPKAMKG TIMSFWTLSV TVGNLWVLLA NVSVKSPTVT EQIVQTGMSV 
481:	TAFQMFFFAG FAILAAIVFA LYARSYQMQD HYRQAT