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2.A.17.4.8
Solute carrier family 15 member 2 (Kidney H+:peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2, PEPT2) (Verri et al. 2016).

Accession Number:Q16348
Protein Name:Solute carrier family 15 member 2
Length:729
Molecular Weight:81783.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

Genevestigator: Q16348
eggNOG: COG3104
HEGENOM: HOG000285186
Entrez Gene ID: 6565   
Pfam: PF00854   
KEGG: hsa:6565   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0042895 F:antibiotic transporter activity
GO:0042936 F:dipeptide transporter activity
GO:0015334 F:high affinity oligopeptide transporter activity
GO:0015333 F:peptide:hydrogen symporter activity
GO:0015893 P:drug transport
GO:0015031 P:protein transport

References (3)

[1] “Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney.”  Liu W.et.al.   7756356
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 
61:	YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 
121:	YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER 
181:	TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK 
241:	IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 
301:	RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD 
361:	FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN 
421:	LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS 
481:	VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG 
541:	EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 
601:	IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV 
661:	LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI 
721:	KLETKKTKL