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2.A.17.4.9
Solute carrier family 15 member 1 (Intestinal H+:peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1, PepT1).  Takes up oligopeptides of 2 to 4 amino acids with a preference for dipeptides, a major route for the absorption of protein digestion end-products. PepT1 is modified by N-glycosylation, and all six asparagine residues in the large extracellular loop between TMSs 9 and 10 are subject to N-glycosylation.  This allows proper association with the plasma membrane and/or stabilization (Chan et al. 2016).

Accession Number:P46059
Protein Name:Solute carrier family 15 member 1
Length:708
Molecular Weight:78806.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate peptides, H+

Cross database links:

Genevestigator: P46059
eggNOG: COG3104
HEGENOM: HOG000285186
Entrez Gene ID: 6564   
Pfam: PF00854   
KEGG: hsa:6564   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015333 F:peptide:hydrogen symporter activity
GO:0005427 F:proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0007586 P:digestion
GO:0015031 P:protein transport

References (5)

[1] “Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization.”  Liang R.et.al.   7896779
[2] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population.”  Saito S.et.al.   12436193
[5] “Genetic variants of the human dipeptide transporter PEPT1.”  Anderle P.et.al.   16258023

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN LSTAIYHTFV 
61:	ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV SSINDLTDHN HDGTPDSLPV 
121:	HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ FEEGQEKQRN RFFSIFYLAI NAGSLLSTII 
181:	TPMLRVQQCG IHSKQACYPL AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI 
241:	GFAIKNRFRH RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ 
301:	GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK CGFNFTSLKK 
361:	MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL NIGNNTMNIS LPGEMVTLGP 
421:	MSQTNAFMTF DVNKLTRINI SSPGSPVTAV TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK 
481:	PEKGENGIRF VNTFNELITI TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ 
541:	PNFNTFYLEF GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV 
601:	TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI LFAALLLVVC 
661:	VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS GANSQKQM