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2.A.18.1.1
Auxin:H+ symporter (auxin influx), AUX or LAX (Reinhardt et al., 2003; Carraro et al., 2012).  In the PILS (Pin-like) family; members are located in the endoplasmic reticular membrane (Balzan et al. 2014).  Expression patterns of PILS family members have been studied (Mohanta et al. 2015).

Accession Number:Q96247
Protein Name:Aux-1 aka AUX1 aka F16M14.5 aka AT2G38120
Length:485
Molecular Weight:54060.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Auxin, H+

Cross database links:

Genevestigator: Q96247
eggNOG: KOG1303
HEGENOM: HBG320564
RefSeq: NP_565882.1   
Entrez Gene ID: 818390   
Pfam: PF01490   
KEGG: ath:AT2G38120   

Gene Ontology

GO:0009986 C:cell surface
GO:0005768 C:endosome
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0010011 F:auxin binding
GO:0010328 F:auxin influx transmembrane transporter acti...
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport
GO:0009734 P:auxin mediated signaling pathway
GO:0009926 P:auxin polar transport
GO:0001736 P:establishment of planar polarity
GO:0010311 P:lateral root formation
GO:0009958 P:positive gravitropism
GO:0009624 P:response to nematode
GO:0048829 P:root cap development
GO:0048765 P:root hair cell differentiation

References (20)

[1] “Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism.”  Bennett M.J.et.al.   8688077
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “The aux1 mutation of Arabidopsis confers both auxin and ethylene resistance.”  Pickett F.B.et.al.   16667854
[5] “Ammonium inhibition of Arabidopsis root growth can be reversed by potassium and by auxin resistance mutations aux1, axr1, and axr2.”  Cao Y.et.al.   8278539
[6] “The AXR1 and AUX1 genes of Arabidopsis function in separate auxin-response pathways.”  Timpte C.et.al.   11536712
[7] “Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway.”  Roman G.et.al.   7768447
[8] “Genetic analysis of the effects of polar auxin transport inhibitors on root growth in Arabidopsis thaliana.”  Fujita H.et.al.   9032965
[9] “Differential effects of 1-naphthaleneacetic acid, indole-3-acetic acid and 2,4-dichlorophenoxyacetic acid on the gravitropic response of roots in an auxin-resistant mutant of Arabidopsis, aux1.”  Yamamoto M.et.al.   9697346
[10] “Auxin and ethylene promote root hair elongation in Arabidopsis.”  Pitts R.J.et.al.   10036773
[11] “The Arabidopsis AUX1 gene: a model system to study mRNA processing in plants.”  Marchant A.et.al.   9484486
[12] “AUX1 regulates root gravitropism in Arabidopsis by facilitating auxin uptake within root apical tissues.”  Marchant A.et.al.   10205161
[13] “Auxin is a positive regulator for ethylene-mediated response in the growth of Arabidopsis roots.”  Rahman A.et.al.   11266581
[14] “Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex.”  Swarup R.et.al.   11641271
[15] “Novel auxin transport inhibitors phenocopy the auxin influx carrier mutation aux1.”  Parry G.et.al.   11260496
[16] “Chromosaponin I specifically interacts with AUX1 protein in regulating the gravitropic response of Arabidopsis roots.”  Rahman A.et.al.   11161055
[17] “Cell polarity signaling in Arabidopsis involves a BFA-sensitive auxin influx pathway.”  Grebe M.et.al.   11864575
[18] “Auxin and ethylene response interactions during Arabidopsis root hair development dissected by auxin influx modulators.”  Rahman A.et.al.   12481073
[19] “AUX1 promotes lateral root formation by facilitating indole-3-acetic acid distribution between sink and source tissues in the Arabidopsis seedling.”  Marchant A.et.al.   11910006
[20] “Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1.”  Swarup R.et.al.   15486104

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEGVEAIVA NDNGTDQVNG NRTGKDNEEH DGSTGSNLSN FLWHGGSVWD AWFSCASNQV 
61:	AQVLLTLPYS FSQLGMLSGI VLQIFYGLLG SWTAYLISVL YVEYRARKEK EGKSFKNHVI 
121:	QWFEVLDGLL GSYWKALGLA FNCTFLLFGS VIQLIACASN IYYINDHLDK RTWTYIFGAC 
181:	CATTVFIPSF HNYRIWSFLG LGMTTYTAWY LAIASIIHGQ AEGVKHSGPT KLVLYFTGAT 
241:	NILYTFGGHA VTVEIMHAMW KPQKFKYIYL MATLYVFTLT IPSAAAVYWA FGDALLDHSN 
301:	AFSLMPKNAW RDAAVILMLI HQFITFGFAC TPLYFVWEKV IGMHDTKSIC LRALARLPVV 
361:	IPIWFLAIIF PFFGPINSAV GALLVSFTVY IIPSLAHMLT YRSASARQNA AEKPPFFMPS 
421:	WTAMYVLNAF VVVWVLIVGF GFGGWASVTN FVRQVDTFGL FAKCYQCKPA AAAAHAPVSA 
481:	LHHRL