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2.A.18.2.2
Lysine/histidine transporter, LHT1

Accession Number:Q9FKS8
Protein Name:Lysine histidine transporter 1
Length:446
Molecular Weight:49814.00
Species: [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate lysine, Histidine

Cross database links:

HEGENOM: HBG319901
RefSeq: NP_198894.2    NP_851109.1   
Entrez Gene ID: 834078   
Pfam: PF01490   
KEGG: ath:AT5G40780   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0043090 P:amino acid import

References (8)

[1] “LHT1, a lysine- and histidine-specific amino acid transporter in arabidopsis.”  Chen L.et.al.   9390441
[2] “Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.”  Kaneko T.et.al.   9679202
[3] “Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones.”  Nakamura Y.et.al.   9872454
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “Selective expression of a novel high-affinity transport system for acidic and neutral amino acids in the tapetum cells of Arabidopsis flowers.”  Lee Y.-H.et.al.   15361141
[6] “Arabidopsis LHT1 is a high-affinity transporter for cellular amino acid uptake in both root epidermis and leaf mesophyll.”  Hirner A.et.al.   16816136
[7] “Comprehensive screening of Arabidopsis mutants suggests the lysine histidine transporter 1 to be involved in plant uptake of amino acids.”  Svennerstam H.et.al.   17293438
[8] “Root uptake of cationic amino acids by Arabidopsis depends on functional expression of amino acid permease 5.”  Svennerstam H.et.al.   18681934

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVAQAPHDDH QDDEKLAAAR QKEIEDWLPI TSSRNAKWWY SAFHNVTAMV GAGVLGLPYA 
61:	MSQLGWGPGI AVLVLSWVIT LYTLWQMVEM HEMVPGKRFD RYHELGQHAF GEKLGLYIVV 
121:	PQQLIVEIGV CIVYMVTGGK SLKKFHELVC DDCKPIKLTY FIMIFASVHF VLSHLPNFNS 
181:	ISGVSLAAAV MSLSYSTIAW ASSASKGVQE DVQYGYKAKT TAGTVFNFFS GLGDVAFAYA 
241:	GHNVVLEIQA TIPSTPEKPS KGPMWRGVIV AYIVVALCYF PVALVGYYIF GNGVEDNILM 
301:	SLKKPAWLIA TANIFVVIHV IGSYQIYAMP VFDMMETLLV KKLNFRPTTT LRFFVRNFYV 
361:	AATMFVGMTF PFFGGLLAFF GGFAFAPTTY FLPCVIWLAI YKPKKYSLSW WANWVCIVFG 
421:	LFLMVLSPIG GLRTIVIQAK GYKFYS