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2.A.18.2.4
General amino acid transporter 6, AAP6 (transports all neutral and acidic amino acids tested including aspartate, and basic amino acids are transported with low affinity) (Okumoto et al., 2002)

Accession Number:P92934
Protein Name:AAP6
Length:481
Molecular Weight:53021.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

eggNOG: KOG1303
HEGENOM: HBG319901
RefSeq: NP_199774.1   
Entrez Gene ID: 835025   
Pfam: PF01490   
KEGG: ath:AT5G49630   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015172 F:acidic amino acid transmembrane transporter...
GO:0015175 F:neutral amino acid transmembrane transporte...
GO:0015293 F:symporter activity
GO:0015810 P:aspartate transport
GO:0015827 P:tryptophan transport

References (5)

[1] “Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutant.”  Rentsch D.et.al.   8776904
[2] “Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10718197
[3] “High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis.”  Okumoto S.et.al.   12244056
[4] “Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.”  Fischer W.-N.et.al.   12148530
[5] “A mutation in amino acid permease AAP6 reduces the amino acid content of the Arabidopsis sieve elements but leaves aphid herbivores unaffected.”  Hunt E.et.al.   19755569

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKKKSMFVE QSFPEHEIGD TNKNFDEDGR DKRTGTWMTG SAHIITAVIG SGVLSLAWAI 
61:	AQLGWVAGPA VLMAFSFITY FTSTMLADCY RSPDPVTGKR NYTYMEVVRS YLGGRKVQLC 
121:	GLAQYGNLIG ITIGYTITAS ISMVAVKRSN CFHKNGHNVK CATSNTPFMI IFAIIQIILS 
181:	QIPNFHNLSW LSILAAVMSF CYASIGVGLS IAKAAGGGEH VRTTLTGVTV GIDVSGAEKI 
241:	WRTFQAIGDI AFAYAYSTVL IEIQDTLKAG PPSENKAMKR ASLVGVSTTT FFYMLCGCVG 
301:	YAAFGNDAPG NFLTGFGFYE PFWLIDFANV CIAVHLIGAY QVFCQPIFQF VESQSAKRWP 
361:	DNKFITGEYK IHVPCCGDFS INFLRLVWRT SYVVVTAVVA MIFPFFNDFL GLIGAASFWP 
421:	LTVYFPIEMH IAQKKIPKFS FTWTWLKILS WTCFIVSLVA AAGSVQGLIQ SLKDFKPFQA 
481:	P