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2.A.18.2.5
General amino acid transporter 8, AAP8 (transports all amino acids, but the basic amino acids are transported
with low affinity (Okumoto et al., 2002))

Accession Number:O80592
Protein Name:AAP8
Length:475
Molecular Weight:51815.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

eggNOG: KOG1303
HEGENOM: HBG319901
RefSeq: NP_172472.1   
Entrez Gene ID: 837536   
Pfam: PF01490   
KEGG: ath:AT1G10010   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport

References (3)

[1] “High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis.”  Okumoto S.et.al.   12244056
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “The amino acid permease AAP8 is important for early seed development in Arabidopsis thaliana.”  Schmidt R.et.al.   17476526

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDAYNNPSAV ESGDAAVKSV DDDGREKRTG TFWTASAHII TAVIGSGVLS LAWAIAQLGW 
61:	VAGTTVLVAF AIITYYTSTL LADCYRSPDS ITGTRNYNYM GVVRSYLGGK KVQLCGVAQY 
121:	VNLVGVTIGY TITASISLVA IGKSNCYHDK GHKAKCSVSN YPYMAAFGIV QIILSQLPNF 
181:	HKLSFLSIIA AVMSFSYASI GIGLAIATVA SGKIGKTELT GTVIGVDVTA SEKVWKLFQA 
241:	IGDIAFSYAF TTILIEIQDT LRSSPPENKV MKRASLVGVS TTTVFYILCG CIGYAAFGNQ 
301:	APGDFLTDFG FYEPYWLIDF ANACIALHLI GAYQVYAQPF FQFVEENCNK KWPQSNFINK 
361:	EYSSKVPLLG KCRVNLFRLV WRTCYVVLTT FVAMIFPFFN AILGLLGAFA FWPLTVYFPV 
421:	AMHIAQAKVK KYSRRWLALN LLVLVCLIVS ALAAVGSIIG LINSVKSYKP FKNLD