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2.A.18.2.7
Amino acid permease 2 (Amino acid transporter AAP2)

Accession Number:Q38967
Protein Name:Amino acid permease 2
Length:493
Molecular Weight:54147.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

eggNOG: NOG126188
HEGENOM: HOG000238530
Entrez Gene ID: 830781   
Pfam: PF01490   
KEGG: ath:AT5G09220   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0015800 P:acidic amino acid transport
GO:0015804 P:neutral amino acid transport

References (7)

[1] “Seed and vascular expression of a high-affinity transporter for cationic amino acids in Arabidopsis.”  Frommer W.B.et.al.   8618839
[2] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Differential expression of two related amino acid transporters with differing substrate specificity in Arabidopsis thaliana.”  Kwart M.et.al.   8281191
[5] “Substrate specificity and expression profile of amino acid transporters (AAPs) in Arabidopsis.”  Fischer W.-N.et.al.   7608199
[6] “Developmental control of H+/amino acid permease gene expression during seed development of Arabidopsis.”  Hirner B.et.al.   9675899
[7] “Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.”  Fischer W.-N.et.al.   12148530

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGETAAANNH RHHHHHGHQV FDVASHDFVP PQPAFKCFDD DGRLKRTGTV WTASAHIITA 
61:	VIGSGVLSLA WAIAQLGWIA GPAVMLLFSL VTLYSSTLLS DCYRTGDAVS GKRNYTYMDA 
121:	VRSILGGFKF KICGLIQYLN LFGIAIGYTI AASISMMAIK RSNCFHKSGG KDPCHMSSNP 
181:	YMIVFGVAEI LLSQVPDFDQ IWWISIVAAV MSFTYSAIGL ALGIVQVAAN GVFKGSLTGI 
241:	SIGTVTQTQK IWRTFQALGD IAFAYSYSVV LIEIQDTVRS PPAESKTMKK ATKISIAVTT 
301:	IFYMLCGSMG YAAFGDAAPG NLLTGFGFYN PFWLLDIANA AIVVHLVGAY QVFAQPIFAF 
361:	IEKSVAERYP DNDFLSKEFE IRIPGFKSPY KVNVFRMVYR SGFVVTTTVI SMLMPFFNDV 
421:	VGILGALGFW PLTVYFPVEM YIKQRKVEKW STRWVCLQML SVACLVISVV AGVGSIAGVM 
481:	LDLKVYKPFK STY