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2.A.18.5.1
Vesicular γ-aminobutyric acid (GABA) and glycine transporter (Aubrey et al., 2007)

Accession Number:P34579
Protein Name:UN47 aka UNC-47 aka T20G5.6
Length:486
Molecular Weight:54439.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate Gamma-aminobutyric acid, Glycine

Cross database links:

eggNOG: meNOG05265
HEGENOM: HBG713804
RefSeq: NP_499255.1   
Entrez Gene ID: 176431   
Pfam: PF01490   
KEGG: cel:T20G5.6   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0016021 C:integral to membrane
GO:0040011 P:locomotion
GO:0006836 P:neurotransmitter transport
GO:0018991 P:oviposition

References (2)

[1] “Identification and characterization of the vesicular GABA transporter.”  McIntire S.L.et.al.   9349821
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MASNRFQNLQ NWTNKHVFSN SLDYWNQELN EVPSYQNQPQ TGESGSNPPP HDRLEPIQES 
61:	VVSEQPQKDD INKQEEAKDD GHGEASEPIS ALQAAWNVTN AIQGMFIVGL PIAVKVGGWW 
121:	SIGAMVGVAY VCYWTGVLLI ECLYENGVKK RKTYREIADF YKPGFGKWVL AAQLTELLST 
181:	CIIYLVLAAD LLQSCFPSVD KAGWMMITSA SLLTCSFLDD LQIVSRLSFF NAISHLIVNL 
241:	IMVLYCLSFV SQWSFSTITF SLNINTLPTI VGMVVFGYTS HIFLPNLEGN MKNPAQFNVM 
301:	LKWSHIAAAV FKVVFGMLGF LTFGELTQEE ISNSLPNQSF KILVNLILVV KALLSYPLPF 
361:	YAAVQLLKNN LFLGYPQTPF TSCYSPDKSL REWAVTLRII LVLFTLFVAL SVPYLVELMG 
421:	LVGNITGTML SFIWPALFHL YIKEKTLNNF EKRFDQGIII MGCSVCISGV YFSSMELLRA 
481:	INSADS