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2.A.18.5.2
The vacuolar amino acid transporter AVT1 (catalyzes uptake into yeast vacuoles of large neutral amino acids including tyr, gln, asn, leu and ile)

Accession Number:P47082
Protein Name:AVT1 aka YJR001W aka J1409 aka YJR83.4
Length:602
Molecular Weight:65346.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: P47082
eggNOG: fuNOG06330
HEGENOM: HBG397737
DIP: DIP-5709N
RefSeq: NP_012534.1   
Entrez Gene ID: 853457   
Pfam: PF01490   
KEGG: sce:YJR001W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015186 F:L-glutamine transmembrane transporter activity
GO:0015188 F:L-isoleucine transmembrane transporter acti...
GO:0005302 F:L-tyrosine transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0007034 P:vacuolar transport

References (6)

[1] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.”  Galibert F.et.al.   8641269
[2] “A family of yeast proteins mediating bidirectional vacuolar amino acid transport.”  Russnak R.et.al.   11274162
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[6] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MPEQEPLSPN GRKRSEVHYI SIPLNRGSAF SPDDSVSQFQ SDGFMTRRQS ILDHPVGSFK 
61:	GVNSLSRFAT SLRRANSFRN IELNADNERS FFKESNDETY DPDTLAPALD GRRLSVTLNN 
121:	AGRPRITNLA NNDRVSTASM AIHDDDYGSI QNSTIGDSGS ILRPTASLTE MMSGGAGRRF 
181:	TNNDMDSIVV KRVEGVDGKV VTLLAGQSTA PQTIFNSINV LIGIGLLALP LGLKYAGWVI 
241:	GLTMLAIFAL ATFCTAELLS RCLDTDPTLI SYADLGYAAF GTKGRALISA LFTLDLLGSG 
301:	VSLVILFGDS LNALFPQYST TFFKIVSFFI VTPPVFIPLS VLSNISLLGI LSTTGTVLVI 
361:	CCCGLYKSSS PGSLVNPMET SMWPIDLKHL CLSIGLLSAC WGGHAVFPNL KTDMRHPDKF 
421:	KDCLKTTYKI TSVTDIGTAV IGFLMFGNLV KDEITKNVLL TEGYPKFVYG LISALMTIIP 
481:	IAKTPLNARP IVSVLDVLMN VQHIDEAASA IKRRAAKGLQ VFNRIFINVV FVLIAINFPE 
541:	FDKIIAFLGA GLCFTICLIL PCWFYLRLCK TTIKPWERVA CHVTICISVV LSTLGVGAAI 
601:	IS