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2.A.18.5.4
Vesicular inhibitory amino acid transporter (GABA and glycine transporter; Solute carrier family 32 member 1; Vesicular GABA transporter; VGAT; hVIAAT).  Probably functions by GABA:H+ antiport (Farsi et al. 2016).

Accession Number:Q9H598
Protein Name:Vesicular inhibitory amino acid transporter
Length:525
Molecular Weight:57415.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate Gamma-aminobutyric acid, Amino acids, H+

Cross database links:

Genevestigator: Q9H598
eggNOG: NOG294245
HEGENOM: HOG000220837
Entrez Gene ID: 140679   
Pfam: PF01490   
Drugbank: Drugbank Link   
KEGG: hsa:140679   

Gene Ontology

GO:0051286 C:cell tip
GO:0061202 C:clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0044316 C:cone cell pedicle
GO:0030425 C:dendrite
GO:0044292 C:dendrite terminus
GO:0060077 C:inhibitory synapse
GO:0016021 C:integral to membrane
GO:0044306 C:neuron projection terminus
GO:0005886 C:plasma membrane
GO:0030672 C:synaptic vesicle membrane
GO:0015495 F:gamma-aminobutyric acid:hydrogen symporter activity
GO:0015187 F:glycine transmembrane transporter activity
GO:0007568 P:aging
GO:0006811 P:ion transport
GO:0007269 P:neurotransmitter secretion
GO:0055085 P:transmembrane transport

References (5)

[1] “Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets.”  Chessler S.D.et.al.   12031963
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina.”  Jellali A.et.al.   12115694

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATLLRSKLS NVATSVSNKS QAKMSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM 
61:	DILKAEGEPC GDEGAEAPVE GDIHYQRGSG APLPPSGSKD QVGGGGEFGG HDKPKITAWE 
121:	AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV 
181:	RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ 
241:	KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY 
301:	IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL 
361:	TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA 
421:	CYSGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL 
481:	LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED