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2.A.18.6.1
Neuronal glutamine (System A-like) transporter, GlnT

Accession Number:Q9JM15
Protein Name:GlnT
Length:485
Molecular Weight:53846.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glutamine

Cross database links:

Genevestigator: Q9JM15
eggNOG: roNOG04774
RefSeq: NP_620187.1   
Entrez Gene ID: 170567   
Pfam: PF01490   
KEGG: rno:170567   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport

References (9)

[1] “Cloning and functional identification of a neuronal glutamine transporter.”  Varoqui H.et.al.   10660562
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Na+ transport by the neural glutamine transporter ATA1.”  Albers A.et.al.   11692272
[4] “Glutamine uptake by neurons: interaction of protons with system a transporters.”  Chaudhry F.A.et.al.   11756489
[5] “Ontogeny of the neutral amino acid transporter SAT1/ATA1 in rat brain.”  Weiss M.D.et.al.   12855186
[6] “Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons.”  Mackenzie B.et.al.   12684517
[7] “Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex.”  Melone M.et.al.   15054072
[8] “SNAT expression in rat placenta.”  Novak D.et.al.   16023720
[9] “Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes.”  Ogura M.et.al.   17323379

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMHFKSGLEL TELQNMTVPE DDNVSNDSND FTEVENGQIN SKFISDRESR RSLTNSHLEK 
61:	RKCDEYIPGT TSLGMSVFNL SNAIMGSGIL GLAFALANTG ILLFLILLTS VTLLSIYSIN 
121:	LLLICSKETG CMVYEKLGEQ VFGTTGKLVI FGATSLQNTG AMLSYLFIVK NELPSAIKSL 
181:	MGEEETFSAW YVDGRVLVVM VTFGIILPLC LLKNLGYLGY TSGFSLSCMV FFLIVVIYKK 
241:	FQIPCMNGEQ NSTVSANVTD ACTPKYVTFN SKTVYALPTI AFAFVCHPSV LPIYSELKDR 
301:	SQKKMQMVSN ISFFAMFVMY FLTAIFGYLT FYEKVQSDLL HKYQSTGDIL ILTVRLAVIV 
361:	AVILTVPVLF FTVRSSLFEL AKKTKFHLCR HVLVTIILLV IINLLVIFIP SMKDIFGVVG 
421:	VTSANMLIFI LPSSLYLKIT NQDGDKNTQR IWAALFLALG VLFSLISIPL VIYDWACSSS 
481:	NGEGH