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2.A.18.6.11
SLC38 member 6, SNAT6. Na+-dependent synaptic vesicle amino acid release porter (Gasnier, 2004) (transports amino acids, glutamine, glycine and γ-amino butyric acid (GABA)).  It seems to be the only glutamine transporter in the brain, being present in excitatory neurons, particularly at the synapses (Bagchi et al. 2014).

Accession Number:Q8IZM9
Protein Name:Probable sodium-coupled neutral amino acid transporter 6
Length:456
Molecular Weight:50929.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

HOG000013088HOG000013088
Genevestigator: Q8IZM9 Q8IZM9 Q8IZM9
eggNOG: COG0814 COG0814 COG0814
Entrez Gene ID: 145389   
Pfam: PF01490   
KEGG: hsa:145389    hsa:145389    hsa:145389   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006865 P:amino acid transport
GO:0006814 P:sodium ion transport

References (9)

[1] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534
[4] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534
[7] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEASWGSFNA ERGWYVSVQQ PEEAEAEELS PLLSNELHRQ RSPGVSFGLS VFNLMNAIMG 
61:	SGILGLAYVL ANTGVFGFSF LLLTVALLAS YSVHLLLSMC IQTAVTSYED LGLFAFGLPG 
121:	KLVVAGTIII QNIGAMSSYL LIIKTELPAA IAEFLTGDYS RYWYLDGQTL LIIICVGIVF 
181:	PLALLPKIGF LGYTSSLSFF FMMFFALVVI IKKWSIPCPL TLNYVEKGFQ ISNVTDDCKP 
241:	KLFHFSKESA YALPTMAFSF LCHTSILPIY CELQSPSKKR MQNVTNTAIA LSFLIYFISA 
301:	LFGYLTFYDK VESELLKGYS KYLSHDVVVM TVKLCILFAV LLTVPLIHFP ARKAVTMMFF 
361:	SNFPFSWIRH FLITLALNII IVLLAIYVPD IRNVFGVVGA STSTCLIFIF PGLFYLKLSR 
421:	EDFLSWKKLG AFVLLIFGIL VGNFSLALII FDWINK