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2.A.18.6.12
Solute carrier family 38, member 8, SLC38A8, expressed only in the eye.  This protein is probably a Na+/H+-dependent amino acid transporter which when defective, gives rise to foveal hypoplasia associated with congenital nystagmus and reduced visual acuity (Perez et al. 2014).

Accession Number:A6NNN8
Protein Name:Putative sodium-coupled neutral amino acid transporter 8
Length:435
Molecular Weight:46731.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: A6NNN8 A6NNN8
eggNOG: COG0814 COG0814
HEGENOM: HOG000008036 HOG000008036
Entrez Gene ID: 146167   
Pfam: PF01490   
KEGG: hsa:146167    hsa:146167   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006865 P:amino acid transport
GO:0006814 P:sodium ion transport

References (2)

[1] “The sequence and analysis of duplication-rich human chromosome 16.”  Martin J.et.al.   15616553
[2] “The sequence and analysis of duplication-rich human chromosome 16.”  Martin J.et.al.   15616553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS KAGGVVPAFL 
61:	VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI GKLCEACFLL NLLMISVAFL 
121:	RVIGDQLEKL CDSLLSGTPP APQPWYADQR FTLPLLSVLV ILPLSAPREI AFQKYTSILG 
181:	TLAACYLALV ITVQYYLWPQ GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC 
241:	SMRKRSLSHW ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV 
301:	LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL TILWVTVTLA 
361:	MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI GPRVKCCLEV WGVVSVLVGT 
421:	FIFGQSTAAA VWEMF