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2.A.18.6.13
Sodium-coupled neutral amino acid transporter 7, SNAT7.  Transports L-glutamine in excitatory neurons 9but not astrocytes) as the preferred substrate, particularly at synapses, but also transports L-glutamate and other amino acids with polar side chains such as L-histidine and L-alanine (Hägglund et al. 2011).

Accession Number:Q9NVC3
Protein Name:Putative sodium-coupled neutral amino acid transporter 7
Length:462
Molecular Weight:49966.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: Q9NVC3
eggNOG: COG0814
HEGENOM: HOG000008036
Entrez Gene ID: 55238   
Pfam: PF01490   
KEGG: hsa:55238   

Gene Ontology

GO:0030424 C:axon
GO:0016021 C:integral to membrane
GO:0043025 C:neuronal cell body
GO:0015180 F:L-alanine transmembrane transporter activity
GO:0015182 F:L-asparagine transmembrane transporter activity
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0015186 F:L-glutamine transmembrane transporter activity
GO:0005290 F:L-histidine transmembrane transporter activity
GO:0015190 F:L-leucine transmembrane transporter activity
GO:0015191 F:L-methionine transmembrane transporter activity
GO:0015194 F:L-serine transmembrane transporter activity
GO:0006814 P:sodium ion transport

References (2)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT TSTLGAIFIV 
61:	VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL VILAYCSQAS NERTYQEVVW 
121:	AVCGKLTGVL CEVAIAVYTF GTCIAFLIII GDQQDKIIAV MAKEPEGASG PWYTDRKFTI 
181:	SLTAFLFILP LSIPREIGFQ KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS 
241:	WMAVFNAMPT ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL 
301:	TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL WLRYQGVPVE 
361:	EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG LAACFIFVFP GLCLIQAKLS 
421:	EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ TTANAIFVDL LA