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2.A.18.6.15
Neutral amino acid transporter 5 (Solute carrier family 38 member 5, SNAT5) (System N transporter 2, SN2).  Transports glutamine, histidine and glycine as well as other amino acids.  Present in glial cells where it probably functions in neurotransmitter clearance from synapses (Rodríguez et al. 2014).

Accession Number:Q8WUX1
Protein Name:Sodium-coupled neutral amino acid transporter 5
Length:472
Molecular Weight:51457.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: Q8WUX1
eggNOG: NOG236441
HEGENOM: HOG000013088
Entrez Gene ID: 92745   
Pfam: PF01490   
KEGG: hsa:92745   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015187 F:glycine transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0006811 P:ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N.”  Nakanishi T.et.al.   11243884
[2] “Large-scale cDNA transfection screening for genes related to cancer development and progression.”  Wan D.et.al.   15498874
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELQDPKMNG ALPSDAVGYR QEREGFLPSR GPAPGSKPVQ FMDFEGKTSF GMSVFNLSNA 
61:	IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL TCAGIAGIRA YEQLGQRAFG 
121:	PAGKVVVATV ICLHNVGAMS SYLFIIKSEL PLVIGTFLYM DPEGDWFLKG NLLIIIVSVL 
181:	IILPLALMKH LGYLGYTSGL SLTCMLFFLV SVIYKKFQLG CAIGHNETAM ESEALVGLPS 
241:	QGLNSSCEAQ MFTVDSQMSY TVPIMAFAFV CHPEVLPIYT ELCRPSKRRM QAVANVSIGA 
301:	MFCMYGLTAT FGYLTFYSSV KAEMLHMYSQ KDPLILCVRL AVLLAVTLTV PVVLFPIRRA 
361:	LQQLLFPGKA FSWPRHVAIA LILLVLVNVL VICVPTIRDI FGVIGSTSAP SLIFILPSIF 
421:	YLRIVPSEVE PFLSWPKIQA LCFGVLGVLF MAVSLGFMFA NWATGQSRMS GH