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2.A.18.6.17
Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3)

Accession Number:Q969I6
Protein Name:Sodium-coupled neutral amino acid transporter 4
Length:547
Molecular Weight:60764.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: Q969I6
eggNOG: COG0814
HEGENOM: HOG000013088
Entrez Gene ID: 55089   
Pfam: PF01490   
KEGG: hsa:55089   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport
GO:0006811 P:ion transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.”  Hatanaka T.et.al.   11342143
[2] “A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization.”  Gu S.et.al.   11414754
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534
[6] “SNAT4 isoform of system A amino acid transporter is expressed in human placenta.”  Desforges M.et.al.   16148032
[7] “Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein.”  Shi Q.et.al.   21917917

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDPMELRNVN IEPDDESSSG ESAPDSYIGI GNSEKAAMSS QFANEDTESQ KFLTNGFLGK 
61:	KKLADYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM ANTGIILFII MLLAVAILSL 
121:	YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG KIGAFVSITM QNIGAMSSYL FIIKYELPEV 
181:	IRAFMGLEEN TGEWYLNGNY LIIFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV 
241:	IYKKFQIPCP LPVLDHSVGN LSFNNTLPMH VVMLPNNSES SDVNFMMDYT HRNPAGLDEN 
301:	QAKGSLHDSG VEYEAHSDDK CEPKYFVFNS RTAYAIPILV FAFVCHPEVL PIYSELKDRS 
361:	RRKMQTVSNI SITGMLVMYL LAALFGYLTF YGEVEDELLH AYSKVYTLDI PLLMVRLAVL 
421:	VAVTLTVPIV LFPIRTSVIT LLFPKRPFSW IRHFLIAAVL IALNNVLVIL VPTIKYIFGF 
481:	IGASSATMLI FILPAVFYLK LVKKETFRSP QKVGALIFLV VGIFFMIGSM ALIIIDWIYD 
541:	PPNSKHH